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Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of…
This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan
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Pharmacokinetic and bioequivalence of two formulations of Valsartan/Amlodipin…
Valsartan/amlodipine combination tablets can exert synergistic antihypertensive effects through different mechanisms, significantly lowering blood pressure while also addressing multiple risk factors and comorbidities in patients. This study designed a single-center, randomized, open-label, two-formulations, single-dose, three-cycle, three-sequence, partially repeated crossover controlled trial…
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Valsartan addition to amlodipine is more effective than losartan addition in …
This study evaluated the effects on blood pressure (BP) of valsartan 160 mg or losartan 100 mg addition to amlodipine 5 mg in hypertensive patients.
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Phase III randomized clinical trial of efficacy and safety of amlodipine and …
Effective antihypertensive therapy is essential for achieving optimal blood pressure (BP) control and reducing cardiovascular events. This double-blind, multicenter, randomized trial aimed to compare the antihypertensive efficacy and safety of a combination of amlodipine (AML) and candesartan cilexetil (CC) versus AML monotherapy in patients with essential hypertension (HTN). After a 4-week run…
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Premature Ventricular Contraction–Induced Cardiomyopathy
Premature ventricular contractions are of common occurrence in routine clinical practice. Though generally perceived as of benign consequence in healthy people in the absence of heart disease, their presence can be a harbinger of fatal ventricular tachyarrhythmia in individuals with structural heart disease. With some of the latest insights into the treatment of ventricular tachyarrhythmia, esp…
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Cardiac characteristics in the premature ventricular contraction patients wit…
Background/Aims: Frequent (sustained) premature ventricular contractions (PVCs) lead to ventricular tachycardia (VT), which triggers ventricular fibrillation and sudden cardiac death. The cardiac characteristics and risk prediction in frequent/sustained PVC patients with or without VT have been still in need of investigation. Methods: The data from patients with frequent PVCs via 24 h ambulator…
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Effects of candesartan and amlodipine on cardiovascular events in hypertensiv…
We examined the effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease (CKD) using the data from the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. CKD was defined as proteinuria and/or decreased GFR (o60 ml per min per 1.73m2) at enrollment. Among 2720 subjects with CKD, there were 1376 and 1344 patients…
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Efficacy and Tolerability of Combination Therapy Versus Monotherapy with Cand…
Intensive blood pressure (BP)lowering is important for the treatment of hypertension; however, it has been a challenge to achieve target BP in many patients. The purpose of this study was to explore the optimal dosage of a fixed-dose combination o candesartan cilexetil (CAN) and amlodipine besylate (AML),by examining the tolerability and efficacy of CAN/AML combination therapy compared with th…
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Evaluation of the Efficacy and Tolerability of Combination Therapy With Cande…
Blood pressure is reported to be insufficiently controlledin>50% of patients with hypertension. Guidelines for the management of hypertension recommend using drugs with different mechanisms of action when >1 agent is needed to achieve the blood pressure target. The combination of an angiotens inreceptor blocker and a calcium channel blockeris recommended asthe preferred antihypertensive medicat…
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Effect of Amlodipine + Candesartan on Cardiovascular Events in Hypertensive P…
Combination therapy with calcium channel blockers and angiotensin II receptor blockers is recommended as one of the effective therapies for hypertension. However, it remains unclear whether this combination reduces major adverse cardiovascular events (MACEs) in patients with hypertension with coronary artery disease (CAD). The purpose of the present study was to examine the effects of amlod…
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