The Mortality and various morbidity rates have been substantially reduced by means of exofenous replacement, the cornerstoe in the treatment of respiratory distress syndrome (RDS) in premature infants
There are many clinical trials of surfactant therapy in newborn babies, but making valid comparisons between surfactant preparations is problematic due to the different doses, volumes and treatment schedules used. This article reviews the evidence available from clinical trials comparing different surfactant preparations and describes a meta-analysis of three randomised, controlled trials comp…
The aim of the study was to compare the treatment regimen of three natural surfactants of different extraction and formulation (Alveofact [Surfactant A = SA], Poractant [Surfactant B = SB] and Beractant [Surfactant C = SC]) in neonatal respiratory distress syndrome (RDS). Premature infants of £ 32 weeks’ gestation with birth weight of £ 2,000 g and with established RDS requiring artificial…
Leakage of plasma proteins Into the alveolar space may inhibit surfactant function. We compared the surface properties and the sensitivity to inhlbitory proteins of different organic solvent surfactant extracts and a synthetic surfactant