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Effects of Febuxostat Versus Allopurinol and Placebo in Reducing Serum Urate …
To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function
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Comparison between febuxostat and allopurinol uric acid-lowering therapy in p…
Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative stress marker. The novel antihyperuricemic drug febuxostat is a potent non-purine selective xanthine oxidase inhibitor. The present study examined the UA-lowering and prognostic effects of febuxostat in patients with HF compared with conventional allop…
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Risk of cutaneous adverse reactions associated with allopurinol or febuxostat…
Allopurinol carries a well‐known risk of cutaneous adverse reactions (CARs). Although febuxostat, a xanthine‐oxidase inhibitor with different chemical structure, has been considered an alternative to allopurinol, post‐marketing case reports of life‐ threatening febuxostat‐related CARs have been reported. We aimed to compare the risk of CARs between allopurinol and febuxostat in real…
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