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The Antihyperglycemic Drug a-Lipoic Acid Stimulates Glucose Uptake via Both G…
The cofactor of mitochondrial dehydrogenase complexes and potent antioxidant a-lipoic acid has been shown to lower blood glucose in diabetic animals. a-Lipoic acid enhances glucose uptake and GLUT1 and GLUT4 translocation in 3T3-L1 adipocytes and L6 myotubes, mimicking insulin action.
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Lipoic Acid Reduces the Activities of Biotin-Dependent Carboxylases in Rat Liver
In the past, lipoic acid has been administered to patients and test animals as therapy for diabetic neuropathy and various intoxications. Lipoic acid and the vitamin biotin have structural similarities. We sought to determine whether the chronic administration of lipoic acid affects the activities of biotin-dependent carboxylases. For 28 d, rats received daily intraperitoneal injections of one …
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Chromium, Glucose Intolerance and Diabetes
Within the last 5 years chromium (Cr) has been shown to play a role in glucose intolerance, Type 2 diabetes mellitus (Type 2 DM), and gestational diabetes. In addition, diabetes and the neuropathy of a patient on home parenteral nutrition were alleviated when supplemental Cr was added to total parenteral nutrition (TPN) solutions. In a study conducted in China that has been supported by studies…
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