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Investigation of prion removal/inactivation from chromatographic gel
Concerns about the potential for prions to be retained on chromatography gels during the manufacture of plasma products prompted development of an investigational strategy for detecting infectious prions bound to gels. The objective was to firstly examine methods of implanting gels intracerebrally (IC) in mice, then to examine prion cleaning from a scaled-down version of the DEAE Sepharose colu…
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Prion-removal capacity of chromatographic and ethanol precipitation steps use…
Although there is no epidemiological evidence to suggest that classical Creutzfeldt–Jakob disease (CJD) is transmitted through blood or blood products, the variant form (vCJD) has been implicated in transmission via packed red blood cells. The potential threat of the infectious agent contaminating plasma pools has led to manufacturing processes being examined for capacity to remove prions. Th…
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Peran Albumin dalam Penatalaksanaan Sirosis Hati
Infus albumin telah dipakai sejak puluhan tahun yang lalu sebagai salah satu pilihan terapi dalam praktek medis. Tujuannya adalah mengatasi kondisi hipoalbuminemia pada berbagai penyakit. Menurunnya kadar albumin dapat menjadi penyebab terjadinya kelainan tetapi lebih banyak merupakan komplikasi penyakit yang diderita sebelumnya. Banyaknya data yang membuktikan bahwa kadar albumin darah berka…
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The urine albumin-to-creatinine ratio is a reliable indicator for evaluating …
This study investigated the correlation between the albumin-to-creatinine ratio in the urine and 24-hour urine proteinuria and whether the ratio can predict chronic kidney disease progression even more reliably than 24-hour proteinuria can, particularly in primary IgA nephropathy
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Correlation between urinary albumin to creatinine ratio and systemic glycocal…
Increased capillary permeability in sepsis is associated with several complications and worse outcomes. Glycocalyx degradation, marked by increased serum syndecan-1 levels, alters vascular permeability, which can manifest as albuminuria in the glomerulus. Therefore, elevated urinary albumin to creatinine ratio (ACR) potentially provides an index of systemic glycocalyx degradation. The aim of…
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Diagnosis and management of nephrotic syndrome
NEPHROTIC SYNDROME IS A WELL KNOWN PRESENTATION OF KIDNEY DISEASE WITH A TRIAD of clinical features namely oedema, substantial proteinuria (> 3.5 g/24 hours) and hypoalbuminaemia (< 30 g/L). It is often associated with hyperlipidaemia, thromboembolism and an increased risk of infection.
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Hepatorenal syndrome: current concepts related to diagnosis and management
Renal failure in cirrhotic patients is a very severe condition. Hepatorenal syndrome has the worst prognosis among all causes of kidney failure in such patients. Hepatorenal syndrome is diagnosed especially in cirrhotic patients with ascites who develop loss renal function, despite diuretic suspension and volume expansion with albumin and for whom other causes of kidney injury have been exclude…
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Perioperative fluid management: science, art or random chaos?
As anaesthetists, we like to believe that the i.v. fluid we administer during surgery is based on a careful consideration of the contemporaneous clinical situation in the particular individual under our care. We estimate deficits; we use clinical assessment and haemodynamic monitoring to characterize circulating blood volume, and we respond to changes with fluid challenges and vasopressors
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Perioperative fluid therapy recommendations for major abdominal surgery. Via …
About 230 million patients undergo surgery each year.1 Reported mortality rates for elective non-cardiac surgery range from 1% to 4%.2 Although less than 15% of inpatient procedures are performed in high-risk patients, such patients account for 80% of deaths
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Three polymorphisms of tumor necrosis factor-alpha and hepatitis B virus rela…
This meta-analysis shows that AA genotype in TNF-a G308A and TNF-a G238A and CT genotype in TNF-a C863T may increase HBV-HCC risk. Therefore, HBV infection seemed to be a more important factor for tumorigenesis of HCC than genetic predisposition in G308A of TNF-a, and interaction between TNF-a C863T polymorphisms and HBV infection might be associated with increased HCC risk
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