Many chronic lung diseases are characterized by the hypersecretion of mucus. In these conditions, the administration of mucoactive agents is often indicated as adjuvant therapy. N-acetylcysteine (NAC) is a typical example of amucolytic agent. A retrospective review of patients with pulmonary aspergillosis treated at the National Aspergillosis Centre in Manchester,United Kingdom,with NAC between…
Asthma is affecting more than 300 million people worldwide, which represents the most common chronic disease among children. We previously found that mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) modulated the immune response on Th2-mediated asthma in vivo and in vitro. This study further evaluated the immunomodulatory effects of MSCs from human embryonic …
The study aimed to evaluate the anatomical differences between positional and non-positional OSA, and to identify the potential predictors for distinguishing between these two types of OSA
Tuberculosis remains a worldwide problem despite well documented, well publicised methods of prevention and cure. Poverty and HIV infection are major reasons for its persistence.1 2 We review the diagnosis, treatment, and prevention of tuberculosis
Despite global efforts to eliminate tuberculosis, the disease remains of huge global public health problem. Prompt and accurate diagnosis of pulmonary tuberculosis is essential to ensure appropriate therapy. Chest radiography, sputum smear microscopy, mycobacterial culture, and nucleic acid amplification test are essential diagnostic elements, and appropriate use of recently introduced molecula…
It has long been recognized that tuberculosis (TB) induces both protective and tissue damaging immune responses. This paper reviews nearly two centuries of evidence that protection and tissue damage are mediated by separate disease entities in humans. Primary TB mediates protective immunity to disseminated infection while post-primary TB causes tissue damage that results in formation of caviti…
Studies focusing on pulmonary tuberculosis in advanced age (≥80 years) are lacking. This study aimed to explore treatment delay, outcomes and their predictors in this group
Pada tanggal 31 Desember 2019, Tiongkok melaporkan kasus pneumonia misterius yang tidak diketahui penyebabnya. Dalam 3 hari, pasien dengan kasus tersebut berjumlah 44 pasien dan terus bertambah hingga saat ini berjumlah jutaan kasus. Pada awalnya data epidemiologi menunjukkan 66% pasien berkaitan atau terpajan dengan satu pasar seafood atau live market di Wuhan, Provinsi Hubei Tiongkok. Sampel…
As the global COVID-19 pandemic has progressed, evidence has emerged that some patients are experiencing prolonged multiorgan symptoms and complications beyond the initial period of acute infection and illness. The list of persisting and new symptoms reported by patients is extensive, including chronic cough, shortness of breath, chest tightness, cognitive dysfunction, and extreme fatigue
This study showed there was persistent and significant impairment of exercise capacity and health status in survivors of SARS over 24 months. Health workers who had SARS experienced even more marked adverse impact