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Natural Antibodies Bridge Innate and Adaptive Immunity
Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen elimination, B cell survival and homeostasis, inflammatory diseases, and autoimmunity, there is a lack of clarity about the physiological role of natural IgG and natural IgA because they appear incapable of recognizing Ag…
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Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis
Renal benefits and the risk of herpes zoster were higher for immunosuppressive drugs versus CS. Data on relative and absolute differences are now available, which can be incorporated into patient-physician discussions related to systemic lupus erythematosus medication use
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American College of Rheumatology Guidelines for Screening, Treatment, and Man…
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determination regarding their application to be made by the physician…
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Update on Lupus Nephritis
SLE is a chronic inflammatory disease that affects the kidneys in about 50%of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesi…
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Analysis of IL-6, IL-10, IL-17 levels in the blood of patients with chronic h…
To investigate the role and significance of serum IL-6, IL-10, IL-17 in the occurrence and development of chronic hepatitis B. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-6, IL-10, IL-17 levels and liver function in patients with hepatitis B and relationship between serum viral load in 70 cases of CHB patients and 20 healthy subjects (control group)
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