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Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymor…
Polymorphisms in several genes of the renin–angiotensin system have been implicated as risk factors for myocardial infarction and ischaemic heart disease. In particular, it has been suggested that the angiotensin converting enzyme insertion / deletion 1166 (I /D) polymorphism and the angiotensin II type 1 receptor A C polymorphisms might act synergistically to increase the risk of myocardi…
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Drug-eluting stents versus bare-metal stents for acute coronary syndrome (Review
Approximately 3.7 million people died from acute coronary syndrome worldwide in 2012. Acute coronary syndrome, also known as myocardial infarction or unstable angina pectoris, is caused by a sudden blockage of the blood supplied to the heartmuscle. Percutaneous coronary intervention is often used for acute coronary syndrome, but previous systematic reviews on the effects of drug-eluting stents …
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The evolution of coronary stents
Percutaneous coronary intervention (PCI) is 40 years old this year. From its humble beginnings of experimental work, PCI has transitioned over years with coronary artery stenting now a standard medical procedure performed throughout the world
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Acute Limb Ischemia
A 57-year-old man presents with an acute onset of left foot pain, numbness, and partial loss of motor function. Four months ago, he underwent endovascular treatment for disabling claudication, which included placement of overlapping polytetrafluoroethylene- coated stents in the left superficial femoral and popliteal arteries. His popliteal and pedal pulses are absent, and the foot is cool and …
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Stress echocardiography combined with cardiopulmonary exercise testing: Openi…
According to consensus recommendations, a diagnosis of heart failure with preserved ejection fraction (HFpEF) can be obtained when three requirements are met simultaneously: signs and symptoms of heart failure; preserved left ventricular (LV) global systolic performance (ejection fraction by echocardiography >50% and LV end-systolic volume
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Cerebral Intraparenchymal Hemorrhage : A Review
Although spontaneous intraparenchymal hemorrhage (IPH) accounts for less than 20%of cases of stroke, it continues to be associated with the highest mortality of all forms of stroke and substantial morbidity rates
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Advances in understanding the molecular mechanisms of venous thrombosis
Venous thromboembolism (VTE) represents a leading cause of global mortality, however, the determinants that contribute to thrombus development remain incompletely understood. In this review, we discuss the role of inherited abnormalities of blood coagulation in VTE pathogenesis. In addition, we also consider recent emerging data suggesting other molecular and cellular determinants may also c…
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Interventions to prevent hemodynamic instability during renal replacement the…
Hemodynamic instability related to renal replacement therapy (HIRRT) may increase the risk of death and limit renal recovery. Studies in end-stage renal disease populations on maintenance hemodialysis suggest that some renal replacement therapy (RRT)-related interventions (e.g., cool dialysate) may reduce the occurrence of HIRRT, but less is known about interventions to prevent HIRRT in critica…
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Pre- and post-treatment with amiodarone for elective electrical cardioversion…
Clinicians pre-treat patients with amiodarone to increase the efficacy of electrical cardioversion for atrial fibrillation (AF). We conducted a systematic review and meta-analysis of randomized controlled trials comparing pre- and post-treatment for electrical cardioversion with amiodarone versus no therapy on (i) acute restoration and (ii) maintenance of sinus rhythm after 1 year. We searched …
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Nutrition and chronic kidney disease
The incidence of malnutrition disorders in chronic kidney disease (CKD) appears unchanged over time, whereas patient-care and dialysis techniques continue to progress. Despite some evidence for cost-effective treatments, there are numerous caveats to applying these research findings on a daily care basis. There is a sustained generation of data confirming metabolic improvement when patients con…
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