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Pulmonary characteristics in COPD and mechanisms of increased work of breathing
Mechanical characteristics and gas exchange inefficiencies of the lungs contribute to increased work of ventilation in chronic obstructive pulmonary disease (COPD) at rest and exercise, and the energy cost of ventilation is increased in COPD at any external work level. Assuming typical ventilatory variables and respiratory characteristics, we estimated the relative contributions of inspiratory …
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The Global Impact of Respiratory Disease – Second Edition
The World Health Organization (WHO) launched the Global Alliance Against Respiratory Diseases (GARD) in 2006 with the aim to bring together the combined knowledge of national and international organisations, institutions and agencies to improve the lives of more than one billion people affected by chronic and acute respiratory diseases
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Pathophysiology and Classification of Respiratory Failure
Respiratory failure is a condition in which the respiratory system fails in one or both of its gas exchange functions. It is a major cause of morbidity and mortality in patients admitted to intensive care units. It is a result of either lung failure, resulting in hypoxemia, or pump failure, resulting in alveolar hypoventilation and hypercapnia. This article covers the basic lung anatomy, pathop…
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Therapy Duration and Long Term Outcomes TB
Tuberculosis is classified as either pulmonary or extra-pulmonary (EPTB). While much focus has been paid to pulmonary tuberculosis, EPTB has received scant attention. Moreover, EPTB is viewed as one wastebasket diagnosis, as “the other” which is not pulmonary
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Tuberculosis
Despite the availability of a cheap and effective treatment, tuberculosis still accounts for millions of cases of active disease and deaths worldwide. The disease disproportionately affects the poorest persons in both high-income and developing countries
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Therapy duration and long-term outcomes in extra-pulmonary tuberculosis
Tuberculosis is classified as either pulmonary or extra-pulmonary (EPTB). While much focus has been paid to pulmonary tuberculosis, EPTB has received scant attention. Moreover, EPTB is viewed as one wastebasket diagnosis, as “the other” which is not pulmonary
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Diagnosis and Treatment of Extrapulmonary Tuberculosis
Extrapulmonary tuberculosis (EPTB) constitutes about 20% of all cases of tuberculosis (TB) in Korea. Diagnosing EPTB remains challenging because clinical samples obtained from relatively inaccessible sites may be paucibacillary, thus decreasing the sensitivity of diagnostic tests. Whenever practical, every effort should be made to obtain appropriate specimens for both mycobacteriologic and hist…
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Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis
A previous meta-analysis suggested that the treatment with erdosteine was associated with significant amelioration of the cumulative global efficacy index and symptoms in comparison to placebo or other mucolytics. However, this conclusion was criticized because the meta-analysis, as it had been done, made it impossible to preclude the potential operation of selection biases within and across t…
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The State of The Laryngoscope 2017.
I am pleased to report on the recent developments in The Laryngoscope—the official journal of the Triological Society and part of the Society’s outstanding publishing franchise. The Laryngoscope has been in publication since July 1896. It is an honor to be associated with this prestigious journal, which has had a historic and ongoing impact on our specialty
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Classics from The Laryngoscope: Celebrating 120 Years of Impact
In this issue, we have reprints from two classic articles, which were published in this journal, both on the field of outcomes research. It gives me great pleasure to write this—outcomes research being my own area of academic interest—and also great pride that these two seminal papers by pioneers in the field were published in The Laryngoscope
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