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Non-alcoholic fatty liver disease: What the clinician needs to know
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic. Though highly frequent, only about one fifth of affected subjects are at risk of developing the progressive form of the disease, non-alcoholic steatohepatitis with fibrosis.
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Gastroesophageal reflux disease and chronic cough: A possible mechanism eluci…
The pathophysiological mechanism(s) of gastroesophageal reflux disease (GERD)‐related chronic cough (CC) is unclear. We aimed to determine the mechanism of reflux‐induced cough by synchronous monitoring of reflux episodes, esophageal motility, and cough
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Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and E…
Two population, intervention, comparison, outcome (PICO) questions were addressed by systematic review: (1) Can therapy for gastroesophageal reflux improve or eliminate cough in adults with chronic and persistently troublesome cough? and (2) Are there minimal clinical criteria to guide practice in determining that chronic cough is likely to respond to therapy for gastroesophageal reflux?
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Typical symptoms and not positive reflux cough correlation predict cure of ga…
The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux related chronic cough after anti-reflux surgery
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The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Earl…
The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%–15% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in th…
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Diagnosis and Management of Cholestatic Liver Disease
Cholestasis (slowing of bile flow) may be acute or chronic and affect any age group. In infants and children the causes often are congenital or inherited and as a result of improved management some affected children now survive to adulthood. Although jaundice is a hallmark of cholestasis it may be absent, particularly in adults with chronic cholestatic liver disease most of whom are entirely as…
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Reference standard of total bile acid concentration of Chinese pregnant women…
The criterion of total bile acid (TBA) concentration for the diagnosis of intrahepatic cholestasis in pregnant women remains debated. The purpose of this study was to establish a reference range of TBA concentration in Chinese pregnant women. Clinical data of Chinese women aged > 18 years with singleton pregnancy were retrospectively analyzed. The blood samples were collected during pregnancy a…
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Ultrasound versus liver function tests for diagnosis of common bile duct ston…
Ultrasound and liver function tests (serum bilirubin and serum alkaline phosphatase) are used as screening tests for the diagnosis of common bile duct stones in people suspected of having common bile duct stones. There has been no systematic review of the iagnostic accuracy of ultrasound and liver function tests
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Clinical effectiveness of cell therapies in patients with chronic liver disea…
Chronic liver disease (CLD) is a major health burden worldwide. Liver cirrhosis, a form of CLD is the fifth most common cause of death in the UK. Acute-on-chronic liver failure (ACLF) is the result of an acute insult superimposed on patients with liver cirrhosis as a result of precipitating events such as infection or bleeding. ACLF has a high associated mortality as a result of multi-organ …
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Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell…
Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We assessed the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) and haemopoietic stem-cell infusions in patients with liver cirrhosis.
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