Although the treatment of chronic subdural haematoma by burr hole drainage has been performed inrnthe past with or without using a closed drainage system, the problem of intracranial air entrapment stillrnpersists and can cause a deterioration in the level of consciousness or seizures in the postoperative period.rnCerebral infarction may also develop a few days after surgery because of the intr…
Frailty is a common clinical syndrome in older adults, which carries an increased risk for poor health outcomes, including falls, incident disability, hospitalization, and mortality. Elucidating its cause and natural history is therefore critical for identifying high-risk subsets and new arenas for frailty prevention and treatment
Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule c…
Gouty arthritis is uncommon in childhood and adolescence. On the other hand, there has been no report of cases with development of gouty arthritis with post-streptococcal acute glomerulonephritis (PSAGN) in pediatric patients. Here we report the case of a mildly obese 12-year-old boy with PSAGN complicated by gouty arthritis of the left first metatarsophalangeal joint. On follow-up, it was conf…
Neurology and psychiatry share common historical origins and rely on similar tools to study brain disorders. Yet, the practical integration of medical and scientific approaches across these clinical neurosciences has remained elusive. While much has been written about the need to incorporate emerging systems-level, cellular-molecular and genetic-epigenetic advances into a science of mind for ps…
To describe pharmacy curricula in psychiatry and neurology and to report on neuropsychiatric pharmacy specialists’ views on optimal curriculum
To determine whether the virtual reality as a distracting intervention could reduce pain and fear in school-age children receiving intravenous injections at an emergency department
In this article, the 2010 European League against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA) with synthetic and biological disease-modifying antirheumatic drugs (sDMARDs and bDMARDs, respectively) have been updated. The 2013 update has been developed by an international task force, which based its decisions mostly on evidence from three systematic litera…
Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routine clinical practice, but these recommendations need to be re-evaluated for appropriaten…
Rheumatoid Arthritis (RA), a chronic systemic inflammatory disease which affects approximately 1% of the population, is classically characterized by inflammation and synovitis that leads to cartilage damage and juxta-articular bone destruction. Accumulating evidence indicates that a major cause of death among RA patients is Cardio Vascular Disease (CVD), in excess of that in the general population