Objective: To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium
Two progesterone presentations, a vaginal application of 90 mg progesterone per day (Crinone) or 300 mg progesterone administered orally (Utrogestan), were compared for luteal phase support of patients undergoing an in-vitro fertilization (IVF) procedure. A total of 283 patients were randomly allocated to either treatment. The treatment started within 24 h after the embryo transfer procedure an…
An effective and convenient method to administer progesterone (P) would be useful. Injections assure reliable absorption1 but are painful. Vaginal P suppositories avoid the pain of injection and are well absorbed, but suppositories sustain P levels less effectively. Suppositories are difficult to place high in the vagina and liquefy at body temperature, which leads to substantial vaginal disc…
OBJECTIVE: To determine if subcutaneous or transvaginal progesterone are preferred by patients after the use of both, based on the influence on their sexual life, global comfort and interference on their normal activities.
The use of cyclodextrin to increase the water solubility of progesterone (P) was described by Pitha as a complex with b-cyclodextrin and derivates to obtain a water soluble formulation (Pitha, J.: US patent n. 4,727,064). Hydroxypropyl-b-cyclodextrin (HPBCD) has a high water solubility which allows the solubilization of high quantity of P. Considering a 1:2 guess/host complex stoichiometry it…
Dulu, asap tembakau dipercaya membawa berkah, simbol spiritual, bahkan dianggap menyehatkan. Hingga akhirnya sains berbicara lain. Kini, dua puluh tahun terakhir, muncul babak baru: e-cigarette dan vape. Awalnya diciptakan dengan niat baik yaitu untuk membantu perokok beralih ke pilihan yang lebih “sehat.” Tapi apakah benar tubuh kita menyambutnya dengan lebih baik? Mari kita lihat…
This study aims to evaluate the efficacy and safety of multiple or single-dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta-analysis was conducted based on randomized controlled trials (RCTs) comparing IVIB with placebo or other analgesic and antipyretic medications for postoperative pai…
Ibuprofen first came to market about 50 years ago and rapidly moved to over-thecounter (OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health Products (ANSM) of France issued a warning for NSAID uses by patients with infectious diseases based on an analysis of 20 years of real-world safety data on ibuprofen and ketoprofen. Nevertheless, ibuprofen remains a mainst…
Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high fever‑based complications. This study primarily sets out to observe and compare the efficacy of intravenous administration of paracetamol and ibuprofen drugs on fever in adult patients with tonsillopharyngitis
Non-steroidal anti-inflammatory drugs (NSAIDs) are popularly used in the management of acute postoperative pain. Intravenous (IV) ketorolac has been used for several years for this purpose. Recently, IV ibuprofen has been introduced for the management of postoperative pain. This review aims to compare the efficacy of these two NSAIDs in managing acute postoperative pain. After registering the p…