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Cytokine Storm
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reminded us of the critical role of an effective host immune response and the devastating effect of immune dysregulation. This year marks 10 years since the first description of a cytokine storm that developed after chimeric antigen receptor (CAR) T-cell therapy1 and 27 years since the term was first used in the liter…
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Diagnosis dan Penanganan Terkini Bronkiolitis pada Anak
Bronkiolitis adalah infeksi saluran napas bawah pada bayi yang umumnya disebabkan oleh infeksi Respiratory Syncytial Virus (RSV), ditandai dengan gejala peradangan akut, edema, dan nekrosis dinding sel epitel saluran napas kecil disertai peningkatan produksi mukus. Rendahnya kadar vitamin D turut berperan dalam perkembangan penyakit ini. Gejala dan tanda umumnya dimulai dari batuk dan pilek, da…
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Bronchiolitis
Bronchiolitis is the most common lower respiratory tract infection in children. The condition forms part of the spectrum of viral lower respiratory tract infection that includes bronchiolitis, viral pneumonia, and viral-induced wheeze. In polar hemispheres (north and south), bronchiolitis is a seasonal disease, dominating winter months, with a peak over 6 to 8 weeks around the winter solstice. …
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Trends in Bronchiolitis Hospitalizations in the United States: 2000–2016
To investigate the temporal trend in the national incidence of bronchiolitis abstract hospitalizations, their characteristics, inpatient resource use, and hospital cost from 2000 through 2016.
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Persistence of SARS-CoV-2 RNA in post-mortem swab 35 days after death: A case…
Post-mortem swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA detection have been recommended by several Scientific Committees and Institutions as a standard procedure for post-mortem assessment of potential Coronavirus Disease-19 (COVID-19) related deaths. To date there is no data about the SARS-CoV-2 RNA detectability period in human bodies after death. The present ca…
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Post-mortem viral dynamics and tropism in COVID-19 patients in correlation wi…
The persistence of SARS-CoV-2 after death of infected individuals is unclear. The aim of this study was to investigate the presence of SARS-CoV-2 RNA in different organs in correlation with tissue damage and post-mortemviral dynamics in COVID- 19 deceased. Twenty-eight patients (17 males, 11 females; age 66–96 years; mean 82.9, median 82.5 years) diagnosed with COVID-19 were studied. Swabs…
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Oxygen Therapy and Oxygen Toxicity
Oxygen therapy and oxygen toxicity are closely interrelated. In severe hypoxemic states, the difference between the therapeutic and the toxic dosage range for oxygen may be very small.
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OXYGEN TOXICITY AFTER HYPERBARIC OXYGEN THERAPY
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen intermittently in a chamber (either mono- or multiplace chamber) at a pressure greater than one atmosphere absolute (1 ATA). Osteomyelitis of the maxilla is very rare due to the high vasculature of this bone. Hyperbaric oxygen therapy is used in the treatment of refractory osteomyelitis A 24-year-old female received HBOT for treat…
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Paradigms of Oxygen Therapy in Critically Ill Patients
Oxygen administration to patients has potential advantages and some evident drawbacks. Several clinical settings, mainly critical scenarios, demand high oxygen inspired fractions (FiO2) in order to assure safe reserve margins for an eventual arterial desaturation (for example before tracheal intubation in operating room).
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Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the history of this debilitating lung condition. Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support. The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suff…
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