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Serum IL-21 levels associated with chronic hepatitis B and hepatitis B-relate…
The aim of the present study was to investigate the role of interleukin (IL)-21 in chronic hepatitis B virus (HBV) infection. IL-21 stimulates T and B cell responses and plays a role in the control of chronic viral infections. Serum IL-21 levels were measured by enzyme immunoassay in 109 patients with chronic HBV infection at various clinical stages, as well as in 19 healthy controls (HCs).
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Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chin…
In this case-control study, 366 Chinese HBV-infected patients were recruited and divided into hepatocellular carcinoma (HCC; n = 94) and non-HCC (n = 272) groups at The First Affiliated Hospital of Sun Yat-Sen University, from April 2009 to December 2012. In the non-HCC group, the patients were classified into three clinical subsets, 76 patients had chronic hepatitis B, 101 were HBV carriers a…
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Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators o…
Hepatitis B virus (HBV) generally causes self-limiting infection in immunocompetent adults, but establishes chronic infection in some adults and in most maternally infected infants. Factors determining clearance versus persistence are not fully understood. Hydrodynamic injection (HDI) of HBV replicon plasmid via tail vein generally results in quick clearance in immunocompetent adult mice. Here,…
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Current concepts in severe acute and necrotizing pancreatitis: an evidence-ba…
The incidence of acute pancreatitis continues to rise, inducing substantial medical and social burden, with annual costs exceeding two billion dollars in the USA alone. Although the majority of patients develop mild pancreatitis, 20% develop severe and/or necrotizing pancreatitis, requiring advanced medical and interventional care. Morbidity resulting from local and systemic complications as w…
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Pediatric Gastroenterology in Cuba: Evolution and Challenges
The professional practice of pediatric gastroenterology arose in Cuba as an expression of the specialty’s development internationally and Cuba’s new strategies in public health, and in response to national needs for health care expertise in digestive diseases of infants, older children and adolescents
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Correlation of Bone Mineral Density Scores and Proton Pump Inhibitors Use in …
We aimed to identify any correlation between long-term proton pump inhibitor use and low bone mineral density in the elderly
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Variceal bleeding in cirrhotic patients
Variceal bleeding is one of the major causes of death in cirrhotic patients. The management during the acute phase and the secondary prophylaxis is well defined. Recent recommendations (2015 Baveno VI expert consensus) are available and should be followed for an optimal management, which must be performed as an emergency in a liver or general intensive-care unit. It is based on the early admini…
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Does adding variceal status to the Child–Turcotte–Pugh score improve its …
The Child–Turcotte–Pugh (CTP) score is widely used worldwide to predict outcomes across a broad spectrum of liver diseases, mainly cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in cirrhotic patients, although the variceal status is not incorporated into the classical CTP score. We sought to determine whether the inclusion of variceal sta…
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Cirrhosis of liver: Etiological factors, complications and prognosis
HCV infection is the major risk factor for cirrhosis in our setup. Ascites was the commonest complication. Patients with child-Pugh’s class ‘A’ cirrhosis had significantly longer survival than patients with child-Pugh’s class ‘B’ and ‘C’. A multidisciplinary approach for prevention and control of ever increasing HCV infection must be adopted and to make the public awareness thro…
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Experimental model of tympanic colic (acute abdomen) in chinchillas (Chinchil…
Digestive disorders caused by sudden changes in diet or inappropriate diet are among the most common disorders of the digestive system. Cecal or intestinal tympany, one consequence of inappropriate diet, is characterized by the accumulation of gases, marked distension of the cecum and colon and the induction of inflammatory processes. To know the effects of intestinal tympany on the enteric ple…
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