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Remembering Kanu Chatterjee: A Gentle Giant of Cardiology
On March 4, 2015, Kanu Chatterjee, MBBS, a beloved physician, cardiologist, healer, teacher, and charismatic mentor, passed away peacefully in Iowa City, Iowa, after a brief battle with cancer. His passing has created an irretrievable loss for the field of cardiovascular medicine, because he was the essence of a clinician-teacher-investigator. Kanu was soft-spoken, kind, and wise; he was a pra…
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Hospitalist Career Decisions Among Internal Medicine Residents
Hospital medicine is a rapidly growing field of internal medicine. However, little is known about internal medicine residents’ decisions to pursue careers in hospital medicine (HM).
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Internal Medicine Point-of-Care Ultrasound Curriculum: Consensus Recommendati…
Bedside point-of-care ultrasound (POCUS) is increasingly used to assessmedical patients. At present, no consensus exists for what POCUS curriculum is appropriate for internal medicine residency training programs. This document details the consensus-based recommendations by the Canadian Internal Medicine Ultrasound (CIMUS) group, comprising 39 members, representing 14 institutions across Canada.
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Comparison of total blood volume in normal, preeclamptic, and nonproteinuric …
Our purpose was to demonstrate reduced blood volume in preeclampsia compared with nonproteinuric gestational hypertension and normal pregnancy by use of independent measures of red blood cell and plasma volumes.
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New agents to reduce cholesterol levels: implications for nephrologists
Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the…
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Sepsis and septic shock
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive,rnlong-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arisingrnfrom research in the past 10 years have increased understanding of this problem among clinicians and lay people, andrnhave led to improved outcomes. The World Hea…
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Hypertension, left ventricular hypertrophy, and sudden cardiac death
Hypertension (HTN) is among the most common, noncommunicable disease in the world. Approximately 80 million people (32.6%) in the United States [1] and one billion worldwide suffer from HTN [2], and the prevalence may be even higher as the diagnosis is based on an objective test (i.e., blood pressure measurement). Longterm HTN leads to hypertensive heart disease, and is the result of anatomical…
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Pressure gradient vs. flow relationships to characterize the physiology of a …
Pressure loss vs. flow curves offer a fundamental fluid dynamic synthesis for describing aortic valve pathophysiology. Severe AS does not consistently behave like an orifice (as suggested by Gorlin) or a resistor, whereas TAVI devices behave like a pure resistor. During peak dobutamine, the ratio of aortic to left ventricular pressures during systolic ejection provides a ‘fractional flow r…
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The prognostic value of a new left bundle branch block in patients with acute…
Eight studies involving 105,861 participants were eligible. New LBBB was associated with higher mortality at 30 days (OR: 2.10, 95% CI 1.27 to 3.48) and 1-year follow up (OR: 2.81, 95% CI 1.64 to 4.80), and increased heart failure risk (OR: 2.64, 95% CI 1.84 to 3.77).
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Raynaud's Disease in Children
Six children with primary Raynaud's disease have been studied with plethysmography and multiple-site skin-temperature readings. All six were free of systemic disease. Each demonstrated the characteristic sequence of pallor, cyanosis, and rubor when subjected to generalized cold, but application of local cold produced only modest reduction in skin temperature and digital pulse. Only one child ha…
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