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Heart Failure in the diabetic patient – epidemiology, etiology, prognosis, …
In the type 2 diabetic patient the frequency of heart failure (HF) is increased and the mortality from HF is higher than with non-diabetic HF. The increased frequency of HF is due to the cardiotoxic tetrad of ischemic heart disease, left ventricular hypertrophy, diabetic cardiomyopathy and an extracellular volume expansion resistant to atrial natriuretic peptides
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Pharmacokinetics and Side-Effects of Clonidine
single oral dose of clonidine 309 ~tg was administered to 8 healthy, normotensive subjects and the time course of its plasma concentrations was followed for 24 h.
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Peripartum Cardiomyopathy: Review of the Literature
Peripartum cardiomyopathy (PPCM) is a rare but serious form of cardiac failure affecting women in the last months of pregnancy or early puerperium. Clinical presentation of PPCM is similar to that of systolic heart failure from any cause, and it can sometimes be complicated by a high incidence of thromboembolism
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Recovery From Heart Attack, Biomedicalization, and the Production of a Contin…
In this article, I explore the experience of recovery from a heart attack through an analytic autoethnography. I Discuss the tensions inherent in biomedical subjectivities of health and ill-health during cardiac recovery through three key themes
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Comparing Asian American Women’s Knowledge, Self-Efficacy, and Perceived Ri…
The aim of the study was to compare knowledge and awareness of heart attacks/heart disease and perceived risk for future heart attack in Asian/Pacific Islander women, compared to other racial and ethnic groups.
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Applying the Principles of Homicide by Heart Attack
Homicide by heart attack is a well-established model in forensic pathology that describes death elicited during or immediately after a criminal act where a threat or fear of physical injury is present. After its introduction nearly 4 decades ago, the principle has undergone a handful of modifications but still maintains its core concepts. All cases of this nature during a 20-year period at the …
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The colorectal cancer immune microenvironment and approach to immunotherapies
Colorectal cancer (CRC) is the third most common cancer in the world, with about 1.4 million cases diagnosed worldwide in 2012 [1]. The prognosis for CRC patients is largely dependent on the stage of the tumor at diagnosis. In the USA, the 5-year survival rates following surgical removal of tumors for localized (stage I), regional (stages II and III) and distant (stage IV) cases are 91.1, 71.7…
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Colorectal Cancer: Genetics is Changing Everything
Cancer is fundamentally a genetic disease caused by mutational or epigenetic alterations in DNA. There has been a remarkable expansion of the molecular understanding of colonic carcinogenesis in the last 30 years and that understanding is changing many aspects of colorectal cancer (CRC) care. This article provides a general update on CRC and highlights how genetics is changing clinical care
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Biomarkers in Colorectal Cancer
Colorectal cancer is the third most common cancer worldwide, with 1.36 million people diagnosed in 2012. The prognosis of colorectal cancer is better with an earlier diagnosis. The outcome of colorectal cancer may also be improved by targeting pathways involved in colorectal cancer formation, such as anti-epidermal growth factor receptor (EGFR) therapy
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Cardiovascular Management in Pregnancy: Congenital Heart Disease
Marked advances in the treatment of congenital heart disease (CHD) have resulted in a growing population of adults with CHD, currently estimated at >1 million adults (at least equal to the pediatric population).1 Many of these are young women, facing decisions about childbearing, and will require expert care. A recent analysis of a large nationally representative hospital discharge database in…
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