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New insights into the immunopathogenesis of systemic lupus erythematosus
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes contributions from the environment, stochastic factors, and genetic susceptibility. Great gains have been made in understanding SLE through the use of genetic variant identification, mouse models, gene expression studies, and epigenetic analyses. Collectively, these studies support the concept that defective cl…
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Lupus in crisis: as failures pile up, clinicians call for new tools
It was another bad year for drug development in lupus. The biggest setback for the field came in late August when AstraZeneca announced that its blockbuster hope anifrolumab, an antibody directed at a subunit of the type I interferon receptor, flunked the first of its two pivotal trials. Then came more bad news when UCB and Biogen reported toward the end of October that their phase 2b study of …
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Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% of patients with SLE will develop lupus nephritis. Renal assault during SLE is initiated by genes that breach immune tolerance and promote autoantibody production. These genes might act in concert with other genetic…
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New therapeutic strategies in systemic lupus erythematosus management
The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EUL AR and the ACR , is mostly eminence- based rather than evidence- based. However, knowledge on SLE is growing quickly , and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of…
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Lupus Erythematosus sistemik
SLE adalah p SLE adalah pSLE adalah p SLE adalah p SLE adalah pSLE adalah pSLE adalah penyakit autoimun. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika enyakit autoimun. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika enyakit autoimun. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika enyakit autoimun. Kondisi pasien mungkin berfluktuasi dan berakibat fatal…
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Psoriatic Arthritis
Psoriasis is a common skin disease that is associated with multiple coexisting conditions. The most prevalent coexisting condition, psoriatic arthritis, develops in up to 30% of patients with psoriasis and is characterized by diverse clinical features, often resulting in delayed diagnosis and treatment. Initial reports emphasized a benign course in most patients, but it is now recognized that …
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Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Infl…
Many studies have been undertaken to reveal how tobacco smoke skews immune responses contributing to the development of chronic obstructive pulmonary disease (COPD) and other lung diseases. Recently, environmental tobacco smoke (ETS) has been linked with asthma and allergic diseases in children. This review presents the most actual knowledge on exact molecular mechanisms responsible for the ske…
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Impacts of cigarette smoking on immune responsiveness: Up and down or upside …
Cigarette smoking is associated with numerous diseases and poses a serious challenge to the current healthcare system worldwide. Smoking impacts both innate and adaptive immunity and plays dual roles in regulating immunity by either exacerbation of pathogenic immune responses or attenuation of defensive immunity. Adaptive immune cells affected by smoking mainly include T helper cells (Th1/Th2/T…
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Pedoman Pencegahan Dan Pengendalian Coronavirus Disease (Covid-19)
Coronavirus adalah keluarga besar virus yang menyebabkan penyakit mulai dari gejala ringan sampai berat. Ada setidaknya dua jenis coronavirus yang diketahui menyebabkan penyakit yang dapat menimbulkan gejala berat seperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Coronavirus Disease 2019 (COVID-19) adalah penyakit jenis baru yang belum pernah diidenti…
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Recurrent Acute Rhinosinusitis Prevention by Azithromycin in Children with No…
Recurrent acute rhinosinusitis (RARS) is characterized by multiple episodes of acute rhinosinusitis between which symptoms and signs resolve completely. The role of antibiotic prophylaxis to prevent RARS in children with nonallergic rhinitis (NAR) has not been investigated
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