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Knowledge Sharing Session : Quality Culture - How Mindset and Attitudes Drive…
Kualitas bukan hanya tentang memenuhi standar, tetapi tentang sikap dan pilihan yang kita ambil setiap hari. Kita akan membahas bagaimana mindset dan attitude mampu mengubah performa, budaya dan bahkan hasil akhir. Karena setiap kita adalah champion dari kualitas.
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Knowledge Sharing Session : Tomat - Teknik Optimal Mengatur Aktivitas Terfokus
Di tengah ritme kerja yang serba cepat dan penuh distraksi, pernahkah Dexan merasa waktu habis begitu saja, tugas menumpuk, dan produktivitas terasa semakin jauh dari harapan? Ingat, produktivitas bukan soal bekerja lebih keras tapi bekerja lebih cerdas
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A network meta-analysis of randomized clinical trials in lenalidomide-exposed…
The treatment landscape for relapsed/refractory multiple myeloma (RRMM) is rapidly evolving, particularly for patients exposed or refractory to lenalidomide. With the aim of evaluating the relative efficacy of lenalidomide-free regimens as second-line treatment options, an updated network meta-analysis, incorporating phase II/III randomized controlled trials, has been conducted
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Lenalidomide, ixazomib, or daratumumab maintenance therapy in multiple myeloma
Lenalidomide, ixazomib, and daratumumab have been proposed as maintenance therapies for patients with newly diagnosed multiple myeloma (MM; NDMM). There are, however, no randomized controlled trials (RCTs) comparing them. We conducted a network metaanalysis (NMA) of RCTs comparing these agents against placebo in NDMM. A Bayesian NMA model was used to assess the relative effects of competing tre…
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Mechanism of action of lenalidomide in hematological malignancies
Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-amino-glutamyl analogue of thalidomide that lacks the neurologic side effects of sedation and neuropathy and has emerged as a drug with activity against various hematological and solid mali…
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Aldosterone’s Rapid, Nongenomic Effects Are Mediated by Striatin: A Modulat…
The cellular responses to steroids are mediated by 2 general mechanisms: genomic and rapid/ nongenomic effects. Identification of the mechanisms underlying aldosterone (ALDO)’s rapid vs their genomic actions is difficult to study, and these mechanisms are not clearly understood. Recent data suggest that striatin is a mediator of nongenomic effects of estrogen. We explored the hypothesis that …
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Inositol – Clinical Applications for Exogenous Use
Recent advances in nutritional and biochemical research have documented inositol as an important dietary and cellular constituent. The processes involved in inositol metabolism and its derivatives in the tissues of mammals have been characterized in vivo as well as at the enzymatic level. Biochemical functions defined for phosphatidylinositol in biological membranes include the regulation of ce…
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Potential effect of striatin (DLBS0333), a bioactive protein fraction isolate…
Striatin contained four major bioactive proteins with approximate molecular weight of 8.3, 10.9, 15.4 and 16.7 kDa. In addition to proteins, striatin also contained amino acids (10 essential and 7 non essential amino acids), fatty acids (palmitic acid, oleic acid, stearic acid, linoleic acid, arachidonic acid), vitamins (vitamin A, vitamin B6) and other nutrients (carbohydrate, dietary fiber, b…
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Channa striatus capsules induces cytokine conversion in pulmonary tuberculosi…
The rate of positive sputum smear decline was more pronounced in the Channa striatus group but did not reach statistically different value between groups. The levels of TNF-α, IFN-γ, and IL-10 were not significantly different in Channa striatus group compared to placebo group at baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly decreased TNF-α, I…
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Efficacy and safety of domperidone and metoclopramide on human milk productio…
Breastfeeding is the most advantageous nutrition for infants because of its many health benefits. However, lactation insufficiency is a prevalent issue among women, particularly those who give birth prematurely. Galactagogues, such as domperidone and metoclopramide, have been reported and may be beneficial for lactation insufficiency. However, the optimal pharmacological galactagogue remains un…
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