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The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde
Chronic hepatitis B (CHB) is a major health problem worldwide and is associated with significant long-term morbidity and mortality. The hepatitis B virus (HBV) is a hepatotropic virus that is capable of integrating in the host nucleus permanently resulting in lifelong infection. To date, there is no definitive cure for HBV, as our current treatments cannot eradicate the viral reservoir that ha…
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Impact of age on the diagnostic performances and cut-offs of APRI and FIB-4 f…
The APRI AUROC in patients aged
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AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fi…
Liver biopsy is the recognized gold standard for liver fibrosis staging. The aspartate minotransferase to platelet ratio index (APRI) has been proposed as a noninvasive and readily available tool for the assessment of liver fibrosis in chronic hepatitis C (CHC). This study aimed to validate, in a Mexican tertiary health care setting, the diagnostic usefulness of APRI in CHC, nonalcoholic fatty…
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Idiopathic Noncirrhotic Portal Hypertension
Cirrhosis is the most common cause of portal hypertension but a heterogeneous group of clinical entities, collectively referred to as non-cirrhotic portal hypertension (NCPH), can also lead to elevation of the portal venous pressure in the absence of cirrhosis. Common causes of NCPH are nonalcoholic or alcoholic steatohepatitis, primary biliary cholangitis, primary sclerosing cholangitis, conge…
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Clinical Effect of a Glycyrrhizin Preparation on Dermal Pruritus of Chronic M…
Patients who are undergoing maintenance hemodialysis due to chronic renal failure manifest a variety of complications. Out of such complications dermal pruritus has occurred in more than 80% of the patients and is well known to be intractable. No specific therapy for this complication has not been established. S ymptomatic treatment of different kinds are tried to indi vidual patients with unce…
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Evaluation of Effects of Drugs on Dermal Pruritus of Chronic Hemodialysis Pat…
Intractable dermal pruritus is one of the complications of chronic hemodialysis patients. Its frequency is relatively high and is said to reach more than 60% of the patients1)2). In daily practice, we often encounter patients who complain severe skin pruritus. Many ways of treatment have so far been attempted for skin pruritus but no decisive therapy has been found. The reason is considered to …
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Stronger neo-minophagen C (SNMC) for the treatment of chronic hepatitis C
Chronic hepatitis C is a slowly progressive liver disease that may elvove insidiously to cirrhosis and poses an increased risk of hepatocelullar carcinoma (HCC)
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Pruritus and Renal Failure
Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus. Topical and systemic agents as well as broadband ultraviolet phototherapy can be extremely beneficial. Gabapentin has been recently discovered…
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Long-Term Treatment of Chronic Hepatitis C with Glycyrrhizin [Stronger Neo-Mi…
In Japan, hepatitis C virus (HCV) is the single most frequent cause of hepatocellular carcinoma (HCC), resulting in yearly deaths of over 30,000. Although the mechanism of how HCV induces HCC is not clear, persistent HCV infection and necro-inflammatory changes in chronic hepatitis C accelerate the development of liver cirrhosis and can event-tuate in HCC
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An analysis of the efficacy and safety of compound glycyrrhizin injections in…
Drug-induced liver injury (DILI) refers to liver damage caused by drugs. DILI poses a significant challenge in the development of new drugs. The management of DILI mainly involves the withdrawal of the offending drug, and there is a lack of specific therapy. This study sought to evaluate the efficacy and safety of compound glycyrrhizin (CG) injections in DILI patients. Aim To evaluate the ef…
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