Treatment of Advanced Non–Small Cell Lung Cancer in 2018

In this Insights,we characterize recent advances inthe field and describe our framework for the treatment of advanced non–small cell lung cancer (NSCLC). Initial assessment of anewpatient withNSCLC is organized by histologic findings, which in most cases indicate a nonsquamous or squamous cell subtype.

Secondary augmentation rhinoplasty with dermofat graft

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Augmentation Rhinoplasty Using a Folded ‘‘Pure’’ Dermal Graft

Although there are several reports about the use of dermal or dermofat grafts, there are only a few reports about augmentation rhinoplasty performed using a ‘‘pure’’ dermal graft. Authors introduce the refined techniques, clinical experience, and report an aesthetically pleasing result of augmentation rhinoplasty performed using a folded pure dermal graft

Augmentation Rhinoplasty with Dermofat Graft

Even though Augmentation rhinoplasty is very popular surgical procedure, it is not easy to obtain ideal materials for augmentation. Many different synthetic materials are used but frequent complications are seen such as infection, extrusion, deform, and dislocation. Autologous tissues were used for augmentation rhinoplasty.

New G-CSF agonists for neutropenia therapy

Granulocyte colony-stimulating factor (G-CSF; filgrastim) and its pegylated form (pegfilgrastim) are widely used to treat neutropenia associated with myelosuppressive chemotherapy and bone marrow transplantation, AIDS-associated or drug-induced neutropenia, and neutropenic diseases. G-CSF facilitates restoration of neutrophil counts, decreases incidence of infection/febrile neutropenia and redu…

A 12-year retrospective review of bullous systemic lupus erythematosus in cut…

The aim of this study was to investigate the clinical features, laboratory findings, systemic manifestations, treatment and outcome of patients with bullous systemic lupus erythematosus in a tertiary care center in Thailand

Potential Metastatic Locoregional Lymph Nodes on Squamous Cell Carcinoma Lary…

Biomarkers to predict locoregional lymph nodes metastasis is not yet accurate until now. The number of occult metastasis in laryngeal carcinoma varies between 1–65%. A tumor biomarker that can give information on the existence of locoregional lymph node involvement in patients with or without signs of clinical locoregional lymph node involvement, as guidelines whether selective neck dissec…

The influence of different fever definitions on diagnostics and treatment aft…

There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering the TLDF is known to increase the number of episodes of fever in neutropenia (FN). This study aimed to investigate the influence of a lower versus standard TLDF on diagnostics and therapy

Inhibition of oxidative phosphorylation suppresses the development of osimert…

Metabolic plasticity is an emerging hallmark of cancer, and increased glycolysis is often observed in transformed cells. Small molecule inhibitors that target driver oncogenes can potentially inhibit the glycolytic pathway. Osimertinib (AZD9291) is a novel EGFR tyrosine kinase inhibitor (TKI) that is potent and selective for sensitising (EGFRm) and T790M resistance mutations.

EGFR T790M detection and osimertinib treatment response evaluation by liquid …

Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical response of osimertinib treatment is unknown.