Normal Pressure Hydrocephalus in Geriatric Medicine: A Challenge

Normal pressure hydrocephalus (NPH) in elderly patients is reviewed. Since the clinical signs that characterize NPH & in continence, difficulty walking, and dementia & occur frequently in the elderly in association with a wide variety of disorders, attention is paid to the differential diagnosis of NPH on the basis of both clinical findings and laboratory tests. Success rates for treatment o…

Normal Pressure Hydrocephalus: Diagnosis and New Approaches to Treatment

Impairment of gait occurs commonly in the elderly and has a profound impact on individual functional capacity and quality of life. Dementia and urinary incontinence are other common problems encountered in the elderly. In many circumstances, these problems are mutually exclusive, with treatments chosen to address each disease entity separately. When they appear over time in the same patient, ho…

Long-lasting active lifestyle and successful cognitive aging in a healthy eld…

The aim of this study was to determine whether cognitive reserve in the elderly affects the evolution of cognitive performance and what its relationship is with active lifestyles in later life

Epilepsy caused by superficial hemosiderosis of the central nervous system

Superficial hemosiderosis of the central nervous system (CNS) is an uncommon and often unrecognized disorder caused by small repeated hemorrhages into the subarachnoid space, resulting in CNS hemosiderin deposition in the subpial layers. The etiology is reported to be idiopathic in 35% of cases, CNS tumor in 15%, trauma in 13%, and arteriovenous malformation in 9% of cases. It

Treatment of a Case of Advanced Sleep Phase SYndrome by Phase Advance Chronot…

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

-

The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

Osteoarthritis (OA) is a prevalent and debilitating joint disease for which ageing, obesity and chronic inflammation are known risk factors. The central, peripheral and autonomic nervous systems are essential in all metabolic systems, and emerging evidence suggests a role for these systems in OA

Changes in the osteochondral unit during osteoarthritis: structure, function …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and trabecular bone form a biocomposite referred to as the osteochondral unit that is uniquely adapted to the transfer of load. During the evolution of the osteoarthritic process the compositions, functional properties, and structures of these tissues undergo marked alterations. Although pathologica…

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

Transforming growth factor‑β (TGFβ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has an important function in maintaining the differentiated phenotype of articular chondrocytes

The role of metabolism in the pathogenesis of osteoarthritis

Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative prote…

Osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a m…