RELATIONSHIPS BETWEEN SERUM URIC ACID AND BLOOD PRESSURE, METABOLIC VARIABLES…

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Acute Coronary Syndrome

Acute coronary syndrome (ACS) is a major health care and economic burden in the United States and accounts for more than 1 million hospitalizations annually. The morbidity and mortality due to ACS are substantial—nearly half of all deaths due to coronary heart disease occur following an ACS. This review provides an up-to-date summary of the pathophysiology, diagnosis, and treatment of ACS. We…

2015 ESC Guidelines for the management of acute coronary syndromes in patient…

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means

Acute Coronary Syndrome

Acute coronary syndrome (ACS) is the umbrella term for the clinical signs and symptoms of myocardial ischemia: unstable angina, non–ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction. This article further defines ACS and the conditions it includes; reviews its risk factors; describes its pathophysiology and associated signs and symptoms; discusses vari…

2014 NSTE ACS Guidelines Overview

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Extended dual antiplatelet therapy for Asian patients with acute coronary syn…

Recommendations were produced for the following nine risk factors: old age (>65), chronic kidney disease (CKD), diabetes mellitus (DM), recurrent myocardial infarction (MI), multi-vessel disease (MVD), multiple stents, bioresorbable vascular scaffold (BVS) stent, left main stenting and peripheral artery disease (PAD). Strong ischaemic risk factors include DM, recurrent MI, MVD and/or >3 stents;…

Treatment of right heart failure: is there a solution to the problem?

Right heart function is a significant determinant of outcomes across a variety of aetiologies of rightrnventricular (RV) dysfunction. Right heart failure syndrome is characterised by the inability of the rightrnventricle to generate sufficient stroke volume. Management often requires simultaneous execution ofrnmultiple strategies to optimise RV preload, contractility and afterload, while mainta…

Complete heart block due to diphtheritic myocarditis in the present era

Diphtheria continues to be reported from many parts of the world. Complete heart block is rare but often fatalrncomplication of diphtheric myocarditis. We report six children with diphtheric myocarditis who presented withrncomplete heart block. Three patients survived, one with persistent complete heart block. Aggressive supportivernmanagement including transvenous pacing may result in complete…

Efficacy and safety of ticagrelor versus clopidogrel in acute coronary syndro…

Ticagrelor treatment could provide a marginally favorable effect at the expense of an increased risk of dyspnea n real-life situations. This pilot study provides a scientific basis to call for a larger, suitably powered Phase 4 prospective or observational study in this ethnic population.

Systematic review: portal vein thrombosis in cirrhosis

Portal vein thrombosis is encountered in 10–25% of cirrhotics. In terms of pathophysiology, cirrhosis is no longer considered a hypocoagulable state; rather than a bleeding risk in cirrhosis, various clinical studies support a thrombotic potential. Clinical findings of portal vein thrombosis in cirrhosis vary from asymptomatic disease to a life-threatening condition at first presentation