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The Prognostic Significance of Carotid Intima-Media Thickness in Patients Who…
Objectives：Increased carotid intima-media thickness (IMT) is known to be associated with adverse cardiovascular events in the patients with risk factors or established atherosclerosis. However, the prognostic importance of carotid IMT is uncertain in the patients who underwent percutaneous coronary intervention (PCI). We sought to evaluate the association of carotid IMT with major adverse …
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Association of increased carotid intima-media thickness with the extent of co…
To investigate (a) the relation between intima-media thickness (IMT) in carotid arteries and the extent of coronary artery disease (CAD); and (b) whether IMT is predictive of coronary atherosclerosis. The coexistence of severe extracranial atherosclerosis in patients with CAD was also analysed
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Safety of New Oral Anticoagulants for Patients with Chronic Kidney Disease
In daily practice, chemical substances called “direct oral anticoagulants” or DOACs are more convenient to administer when set beside vitamin K antagonists (VKA) due to improved pharmacologic properties, fewer drug interactions and rapid onset of action. The objective of this review was to assess whether DOACs are the alternative for VKA in subjects with mild-to-moderate chronic kidney d…
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Efficacy and safety of statin therapy in older people: a meta-analysis of ind…
Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range ofrnindividuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysisrnof data from all large statin trials to compare the effects of statin therapy at different ages.
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Variant ECG pattern associated with acute proximal left anterior descending o…
Primary percutaneous coronary intervention is the gold-standard treatment for acute coronary artery occlusion. This is primarily diagnosed by ST segment elevation on an ECG accompanying ischaemic-sounding chest pain.
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Anticoagulation in CKD and ESRD
In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKDrnpatients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversialrndue to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for thosernwith CKD. Until studi…
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Renin-angiotensin system in vertebrates: phylogenetic view of structure and f…
Renin substrate, biological renin activity, and/or renin-secreting cells in kidneys evolved at an early stage of vertebrate phylogeny. Angiotensin (Ang) I and II molecules have been identified biochemically in representative species of all vertebrate classes, although variation occurs in amino acids at positions 1, 5, and 9 of Ang I. Variations have also evolved in amino acid positions 3 and 4 …
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Renin–angiotensin system blockade for the risk of cancer and death
The effects of renin–angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) on cancer remain inconsistent
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Statin Treatment in Patients With Intracerebral Hemorrhage
Ever since the publication of the SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) in 2006, neurologists became aware of the fact that statins may increase the risk for future intracerebral hemorrhage (ICH) in patients with previous ischemic stroke or ICH.1,2 At the same time, observational studies reported an increased risk for hemorrhagic transformation or even…
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Pleiotropic Effects of Statins on the Cardiovascular System
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDLcholesterol. Statins may exert cardiovascular protective effects that are in…
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