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Ischemic Strokes After Cardiac Catheterization : Opportune Thrombolysis Candi…
Stroke is an important complication after cardiac catheterization procedures, resulting in death and disability for thousands of patients each year. Common risk factors include advanced age, vascular comorbidities, and more complicated and invasive procedures. Several lines of evidence suggest that these strokes are embolic, from either dislodgement of a clot or atheromatous debris off the aort…
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Risk Assessment and Management of the Mother with Cardiovascular Disease
Advances in medical care, particularly cardiac surgery, over the past half century have led to significant improvements in outcomes for children with chronic medical conditions. Children with structural heart defects, both genetic and acquired, have seen a profound improvement in survival
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Serum Uric Acid and the Renin Angiotensin System in Hypertension
To study whether the renin-angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA). In malignant hypertension, both PRA and the serum uric acid level were higher than in essential hypertension; but in primary aldosteronism or desoxycort…
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Relationships between serum uric acid and blood pressure, metabolic variables…
These data provide evidence that similarly to what described in western Europe, in central and eastern European countries SUA values are closely related to metabolic alterations, including diabetes mellitus, to renal insuffi ciency and CV risk profi le. At variance from other studies, however, no relationship was found with BP control.
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Novel therapies for diabetic kidney disease
Over the past 30 years there have been many complementary therapies developed to achieve glycemic control and have an impact on cardiovascular outcomes, as well as reduce the risk of microvascular disease. The 2 most notable new entries have been the sodium–glucose cotransporter 2 (SGLT2) inhibitors and the glucagon-like peptide-1 (GLP-1) agonists. Both these classes of agents have demonstra…
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Mineralocorticoid Antagonism and Diabetic Kidney Disease
Type 2 diabetes (T2D) is associated with an increased risk of diabetic kidney disease (DKD), cardiovascular disease, and heart failure, in part through activation of the renin-angiotensin-aldosterone system (RAAS). Although recent cardiovascular outcome trials have identified newer therapeutic agents such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1)-…
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Cardiovascular outcomes in diabetic kidney disease: insights from recent clin…
The prevalence of type 2 diabetes is catalyzing a pandemic in kidney disease, with ensuing cardiovascular complications. The effort to identify antidiabetic agents capable of promoting benefits that go beyond the bounds of glucose control has produced remarkable outcomes in recent cardiovascular outcomes trials in patients with type 2 diabetes mellitus, many of whom have diabetic kidney disease.
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Cervical Root Syndrome
The clinical manifestations of the cervical root syndrome may mimic the symptoms of coronary artery disease so closely that errors in diagnosis are common. Complaint of pain in the left side of the chest and arm is insufficient grounds for making a diagnosis of coronary artery disease.
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Connection between the heart and the gut
A 45-year-old man with ulcerative colitis was admitted with bloody diarrhoea and chest pain. Inflammatory markers and high-sensitivity troponin were elevated (C reactive protein 57 mg/L, white cell count 10.65×109/L, neutrophil 6.6×109/L, Troponin-I 663 mmol/L).
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Strategies to increase nitric oxide signalling in cardiovascular disease
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central nervous systems, and crucial steps in the regulation of NO bioavailability in health and disease are well characterized. Although early approaches to therapeutically modulate NO bioavailability failed in clinical trials, an enhanced understanding of fundamental subcellular signalling has enabled a range of …
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