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microRNAs in Essential Hypertension and Blood Pressure Regulation
Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2 % of the entire human DNA support the hypothesis that mechanisms besides coding genes are likely to contribute to BP regulation. Non-coding RNAs, especially microRNAs, are emerging as key players of transcri…
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Cellular and molecular mechanisms of renal fibrosis
Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a major determinant of renal insufficiency. Irrespective of the initial causes, renal fibrogenesis is a dynamic and converging process that consists of four overlapping phases: priming, activation, e…
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Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models an…
Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work correctly. It has a high prevalence and represents a serious hazard to human health and estimated to affects hundreds of millions of people. Diabetes and hypertension are the two principal causes of CKD
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The American Society for Preventive Cardiology: Our 30-year legacy
The American Society for Preventive Cardiology (ASPC) has as its mission “to promote the prevention of cardiovascular disease, advocate for the preservation of cardiovascular health, and disseminate high-quality, evidence-based information through the education of healthcare clinicians and their patients.” The origins of ASPC date back to a working group of National Heart, Lung, and Blood …
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One year of nuclear cardiology in Europe
Since the introduction of the need to use imaging for the monitoring of cardiomyopathies and particularly ischemic cardiomyopathies in international guidelines, articles reporting the place, the accuracy and the prognostic impact of cardiac imaging have grown exponentially. During 2015, the European Journal of Nuclear Medicine and Molecular Imaging published selected pre-clinical, technical an…
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Geriatric Cardiology : A Fellow’s Perspective
Is the term geriatric cardiology redundant? Technically, geriatric cardiology refers to cardiovascular care of patients 65 years of age or older. The United States Census Bureau predicts that by the year 2050, almost 81 million Americans will fall into this demographic. The geriatric population is further broken down into elderly (between ages 75 and 84 years) and very elderly (85 years of ag…
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Cardiac Shock Care Centers
Despite advances over the past decade, the incidence of cardiogenic shock secondary to acute myocardial infarction has increased, with an unchanged mortality near 50%. Recent trials have not clarified the best strategies in treatment. While dedicated cardiac shock centers are being established, there are no standardized agreements on the utilization of mechanical circulatory support and the tim…
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Progress in the monitoring of direct oral anticoagulant therapy
The availability of direct oral anticoagulants (DOACs) has led to a paradigm shift in the field of anticoagulation, with DOACs increasingly being prescribed for patients in preference to vitamin K antagonists and low molecular weight heparin. Despite good experience with the use of these agents at fixed doses, there are clinical scenarios where monitoring is recommended. Data from phase III st…
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Editorial : How Best to Resuscitate Patients With Septic Shock?
What is the best approach for resuscitation of a patien twit hseptic shock? Despite considerable investigation over several decades, this important question still has no clear answer. There is agreement that resuscitation should proceed quickly, for the longer the delay, the greater the physiologic stress and endorgan injury. However, treatment options are principally intravenous fluids and va…
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Dynamic Changes in the ST-T Segment During Sleep in Ischemic Heart Disease
The electrocardiographic pattern during sleep was recorded in 140 patients with chronic ischemic heart disease by the Holter continuous recording system. Among the 97 patients who had fixed abnormal ST-T changes during the day, the severity of the pathologic pattern decreased during sleep in 39, remained unchanged in 35 and became more marked in 23 patients. The deterioration of ST-T changes i…
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