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Prediction of postpartum hemorrhage in women with gestational hypertension or…
To assess whether postpartum hemorrhage can be predicted in women with gestational hypertension or mild preeclampsia at term. Design. A cohort study in which we used data from our multicentre randomized controlled trial (HYPITAT trial). Setting. The study was conducted in 38 hospitals in the Netherlands between 2005 and 2008.
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Heart failure drug treatment
Heart failure is the most common cardiovascular reason for hospital admission for people older than 60 years of age. Few areas in medicine have progressed as remarkably as heart failure treatment over the past three decades. However, progress has been consistent only for chronic heart failure with reduced ejection fraction. In acutely decompensated heart failure and heart failure with preser…
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Atrial fibrillation and stroke: a practical guide
Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly in…
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The role of nitric oxide in cardiovascular diseases
Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role in the protection against the onset and progression of cardiovascular disease. Cardiovascular disease is associated with a number of different disorders including h…
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Nitric oxide and cardiac function
Nitric oxide (NO) participates in the control of contractility and heart rate, limits cardiac remodeling after an infarction and contributes to the protective effect of ischemic pre- and postconditioning. Low concentrations of NO, with production of small amounts of cGMP, inhibit phosphodiesterase III, thus preventing the hydrolysis of cAMP. The subsequent activation of a protein-kinase A cause…
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Transfusion Management of Obstetric Hemorrhage
The importance of transfusion medicine in the management of postpartum hemorrhage (PPH) cannot be overstated and is reflected in the historical record with the first series of successful human-to-human transfusions being performed by James Blundell in 1818, a London obstetrician treating patients with PPH
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Developing a Systematic Approach to Obstetric Emergencies
Comparison of pre- and postassessments revealed improvements in perceived confidence and competence when managing obstetric emergencies. Nurse confidence increased by 35% and nurse competence increased by 32%. The 2-day educational program also realized significant cost savings. Overall costs for the educational program decreased from $94849 to $42974.
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Postpartum Hemorrhage: Management of Massive Transfusion
In women with postpartumhemorrhage, the need to transfuse a large amount of blood products is frequent. The ABCD ofmassive transfusions—Assessment/Activation, Blood products, Complications, and Drugs—can helpmanage this complex situation. There needs to be a definedmethod to activate themassive transfusion protocol and a well-defined means to assess the coagulation status of the patient …
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2018 International Consensus on Cardiopulmonary Resuscitation and Emergency C…
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the second annual summary of International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations that includes the most recent cardiopulmonary resuscitation science rev…
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A new medical therapy for anemia in thalassemia
In this issue of Blood, Piga et al report results of a phase 2, open label, nonrandomized, uncontrolled dose-finding study evaluating the effects of luspatercept on erythroid maturation and differentiation in adult patients with b-thalassemia.1 A high percentage of patients had an increase in hemoglobin or a reduction in transfusion burden, which helped lay the basis for future randomized trials
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