The metabolic syndrome and its components have been associated with hypovitaminosis D in many observational trials. Several mechanisms have been proposed to explain this relationship and include most conditions that are present in patients with the metabolic syndrome. A causal relationship of the association between the metabolic syndrome and hypovitaminosis D, however, has not been demonstr…
Malnutrition is acommonfeature of chronic liver diseases that is often associated with a poor prognosis including worsening of clinical outcome, neuropsychiatric complications as well as outcome following liver transplantation. Nutritional assessment in patients with cirrhosis is challenging owing to confounding factors related to liver failure. The objectives of nutritional intervention in cir…
Osteoporosis is a progressive systemic skeletal disease characterizedby reduced bone mass/density and microarchitectural deterioration of bone tissue. It is a “silent disease” as there are no symptoms prior to a fracture.The prevalence of osteoporosis increases markedly with age.DEXA is regarded as the gold standard technique for diagnosis of osteoporosis
The assessment of nutritional status in patients with cirrhosis is problematic. In addition there are significant sex-related differences in body composition and in the characteristics of tissue loss which limit the usefulness of techniques based on measures of muscle mass and function in women. Techniques which combine subjective and objective variables provide reasonably accurate information…
The worldwide pandemic of 2019 novel coronavirus disease (COVID-19) has posed the most substantial and severe public health issue for several generations, and therapeutic options have not yet been optimised. Vitamin D (in its “parent” form, cholecalciferol) has been proposed in the pharmacological management of COVID-19 by various sources. We aimed to determine whether COVID-19 mortality wa…
Little information is available on the beneficial effects of cholecalciferol treatment in comorbid patients hospitalized for COVID-19. The aim of this study was to retrospectively examine the clinical outcome of patients receiving in-hospital high-dose bolus cholecalciferol. Patients with a positive diagnosis of SARS-CoV-2 and overt COVID-19, hospitalized from 15 March to 20 April 2020, were co…
Vitamin D treatment has been found to decrease the incidence of viral respiratory tract infection, especially in patients with vitamin D deficiency. Whether vitamin D is associated with coronavirus disease 2019 (COVID-19) incidence is unknown
Strenuous physical activity promotes inflammation and depletes muscle glycogen, which may increase the iron regulatory hormone hepcidin. Hepcidin reduces dietary iron absorption and may contribute to declines in iron status frequently observed following strenuous physical activity