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The Mystery of IVIg
An 11-year-old Caucasian female with juvenile dermatomyositis (JDMS) presented to our clinic with a worsening rash and increased proximal muscle weakness. Three years prior to this visit, the patient had been diagnosed with JDMS based on clinical presentation, elevated muscle enzymes, and characteristic findings on muscle biopsy and electromyography. She was successfully managed with chronic …
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A 10% liquid immunoglobulin preparation for intravenous use (Privigen®) in p…
The objective of this study was to evaluate safety and efficacy of Privigen®, a 10% intravenous immunoglobulin (IVIG), in a particular group of paediatric patients (highly sensitive to previous IVIG infusion) affected with Primary Immunodeficiencies (PID)
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L-Proline reduces IgG dimer content and enhances the stability of intravenous…
Liquid intravenous immunoglobulin (IVIG) products offer improved convenience in preparation but often lack sufficient stability to allow room temperature storage. Furthermore, clinical tolerability may be affected due to formation of idiotype/anti-idiotype IgG dimers and/or aggregates. Here we report on the development of a 10% IVIG formulation with optimized stability achieved by the use of L-…
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Nationwide study of therapeutic plasma exchange vs intravenous immunoglobulin…
We compared outcomes of therapeutic plasma exchange (TPE) vs intravenous immunoglobulin (IVIG) among hospitalized patients diagnosed with Guillain-Barré syndrome (GBS).
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Intravenous immunoglobulin for Guillain-Barré syndrome
Guillain-Barré syndrome (GBS) is an acute, paralysing, inflammatory peripheral nerve disease. Intravenous immunoglobulin (IVIg) is beneficial in other autoimmune diseases. This is an update of a review first published in 2001 and previously updated in 2003, 2005, 2007, 2010 and 2012. Other Cochrane systematic reviews have shown that plasma exchange (PE) significantly hastens recovery in GBS co…
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Comparison of efficacy and outcome of intravenous immunoglobulin therapy vers…
Acute inflammatory demyelinating polyneuropathy (AIDP) often described as Guillain-Barre syndrome (GBS) is an ascending neuropathy involving demyelination of peripheral nerves. Very few studies on GBS have been conducted in Indian scenario in recent years. Taking into account this background, we undertook this study to have better outlook to the spectrum of disease and out…
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Efficacy and safety of Privigen® in patients with chronicinflammatory demy…
This prospective, multicenter, single-arm, open-label Phase III study aimed toevaluate the efficacy and safety of Privigen® (10% liquid human intravenous immunoglob-ulin [IVIG], stabilized with L-proline) in patients with chronic inflammatory demyelinatingpolyneuropathy (CIDP). Patients received one induction dose of Privigen (2 g/kg body weight[bw]) and up to seven maintenance doses (1 g/kg…
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Intravenous immunoglobulin for chronic inflammatory demyelinating polyradicul…
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a potentially disabling autoimmune disease causing progressive or relapsing–remitting weakness with or without sensory loss. Previous small trials demonstrated short-term benefit from intravenous immunoglobulin (IVIg), and international guidelines recommend IVIg as an option. However, evidence had been insufficient to persuad…
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Efficacy and safety of Privigen H, a novel liquid intravenous immunoglobulin …
Intravenous immunoglobulin (IVIG) has become a mainstay of treatment for acute and chronic immune thrombocytopenic purpura (ITP). The efficacy and safety of PrivigenH, a new, ready-touse, 10% liquid human IgG formulation, was evaluated in this open-label, multicentre study. PrivigenH infusions (1 g/kg per day for 2 consecutive days, days 1 and 2) were given to 57 adolescent and adult patients w…
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Tolerability of a New 10% Liquid Immunoglobulin for Intravenous Use, Privigen…
The tolerability of L-proline-stabilized Privigen®, a new 10% liquid immunoglobulin for intravenous administration, was assessed at high infusion rates in a Phase III, open-label, single-arm, multicenter study in 45 patients with primary immune deficiencies
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