Alemtuzumab to Treat Refractory Autoimmune Hemolytic Anemia or Thrombocytopen…

Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) are recognized complications of chronic lymphocytic leukemia (CLL) that can be life-threatening if not managed appropriately. Conventional therapies for these autoimmune disorders, such as corticosteroids, splenectomy, and immunosuppressive agents, may not induce complete resolution in all patients, and relapses are c…

Differential diagnosis of ovarian cancer, benign ovarian tumor and endometriosis

We used a combination assay of serum sialyl SSEA-1 antigen (SLX) and CA125 levels, and evaluated the clinical usefulness of this technique for a differential diagnosis of ovarian cancer, benign ovarian tumor and endometriosis. In 82 patients with ovarian tumors, the sera of 20 (64.5%) of 31 with ovarian cancer and 15 (48.4%) of the 31 with endometriosis (endometrial cyst) were positive for both…

Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review an…

Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly encountered disease entity following chemotherapy for cancer treatment. Although only duloxetine is recommended by the American Society of Clinical Oncology (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome for new pharmaceutic therapies and non-pharmaceutic treatments has not been clearly determined

Advanced nasopharyngeal carcinoma in children

Nasopharyngeal carcinoma (NPC) is the most familiar cancer originating in the nasopharynx, and not uncommonly found in the head and neck region in adults. Under appropriate and effective treatment, the outcome subsequent to medical intervention can be relatively good in adults with nasopharyngeal carcinoma. However, NPC is very uncommon in children younger than 10 years, and its incidence incre…

Implications of Prostate Cancer Treatment in Men With Inflammatory Bowel Dis…

To investigate the influences of inflammatory bowel disease (IBD), a rare but morbid disease with increasing incidence, on prostate cancer management decisions. We examined whether prostate cancer treatment differed for men with IBD, and whether treatment choice was associated with risk of IBD flare

Tuberculous meningitis

Uncertainty and doubt dominate all aspects of tuberculous meningitis (TBM). The variable natural history and accompanying clinical features of TBM hinders the diagnosis. Ziehl-Neelsen staining lacks sensitivity and culture results are often insufficiently timely to aid clinical judgement.

Tuberculous meningitis: Diagnostic and therapeutic challenges

Neurologists are often the first medical providers to evaluate patients with possible infectious meningitis. Knowledge of the clinical presentations and cerebrospinal fluid, microbiologic, and neuroimaging findings for different etiologies is essential to make a prompt diagnosis and initiate appropriate treatment

Phyllodes tumors with and without fibroadenoma-like areas display distinct ge…

Breast fibroepithelial lesions (fibroadenomas and phyllodes tumors) are underpinned by recurrent MED12 exon 2 mutations, which are more common in fibroadenomas and benign phyllodes tumors. TERT promoter hotspot mutations have been documented in phyllodes tumors, and found to be more frequent in borderline and malignant lesions. Several lines of evidence suggest that a subset of phyllodes tumors…

A retrospective review of phyllodes tumours of the breast: A single institut…

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Quality improvement in neurology Epilepsy Quality Measurement Set 2017 update

Epilepsy is a common condition in the United States. It is estimated that 1.2% of the populationrnor 3.4 million people have epilepsy. This figure may be underestimated because of potentialrnrepercussions and stigma in disclosing epilepsy.1 Studies have shown that people with epilepsyrnare more likely to be unemployed or unable to work, have lower annual household incomes, bernobese and physica…