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Nebivolol: A Review of its Use in the Management of Hypertension and Chronic…
Nebivolol is a third-generation β-adrenoceptor antagonist. It differs from other β-adrenoceptor antagonists as it combines highly selective β1-adrenoceptor antagonist properties with nitric oxide-mediated vasodilatory actions and beneficial effects on endothelial function. Nebivolol is approved in Europe and several other countries for the treatment of essential hypertension and in Europe fo…
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Efficacy, tolerability and safety of nebivolol in patients with hypertension …
Hypertension is a widely prevalent condition of elevated blood pressure (BP) and is the leading risk factor for the development of cardiovascular disease (CVD). Many patients have additional risk factors such as diabetes mellitus (DM) or previous history of CVD. Nebivolol is a third-generation beta (β)-blockers which has been shown not to influence metabolic parameters in patients with DM. Th…
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A Review of Nebivolol Pharmacology and Clinical Evidence
Nebivolol is a highly selective b1-adrenergic receptor antagonist with a pharmacologic profile that differs from those of other drugs in its class. In addition to cardioselectivity mediated via b1 receptor blockade, nebivolol induces nitric oxide-mediated vasodilation by stimulating endothelial nitric oxide synthase via b3 agonism.
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Management of blood pressure in heart failure
Hypertension is a common comorbidity in patients with heart failure and most drugs that have demonstrated to improve prognosis in this population have the potential to reduce blood pressure. Nonetheless, the relationship between blood pressure and clinical outcomes and the relevance of blood pressure reduction in heart failure remains unclear.
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Premature Ventricular Contraction–Induced Cardiomyopathy
Premature ventricular contractions are of common occurrence in routine clinical practice. Though generally perceived as of benign consequence in healthy people in the absence of heart disease, their presence can be a harbinger of fatal ventricular tachyarrhythmia in individuals with structural heart disease. With some of the latest insights into the treatment of ventricular tachyarrhythmia, esp…
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Cardiac characteristics in the premature ventricular contraction patients wit…
Background/Aims: Frequent (sustained) premature ventricular contractions (PVCs) lead to ventricular tachycardia (VT), which triggers ventricular fibrillation and sudden cardiac death. The cardiac characteristics and risk prediction in frequent/sustained PVC patients with or without VT have been still in need of investigation. Methods: The data from patients with frequent PVCs via 24 h ambulator…
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