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Anaemia in haemodialysis patients of five European countries: association wit…
The Dialysis Outcomes and Practice Patterns Study (DOPPS) is a prospective, observational study based on data collected from nationally representative samples of haemodialysis facilities. The burden of anaemia in haemodialysis patients is substantial, leading to considerable morbidity, mortality and reduced quality of life. This study examines anaemia management and outcomes based on data from …
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Erythropoietin to treat head and neck cancer patients with anaemia undergoing…
Anaemia is associated with poor cancer control, particularly in patients undergoing radiotherapy. We investigated whether anaemia correction with epoetin could improve outcome of curative radiotherapy among patients with head and neck cancer.
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Haemoglobin variability and all-cause mortality in haemodialysis patients: A …
Haemoglobin (Hb) variability has been reported to be associated with mortality in dialysis patients in some but not all studies. We aimed to establish the prognostic significance of Hb variability with all-cause mortality in haemodialysis patients through this meta-analysis
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Types of erythropoiesis-stimulating agents and risk of end-stage kidney disea…
Despite the widespread use of erythropoiesisstimulating agents (ESAs) to treat anaemia, the risk of adverse outcomes associated with the use of different types of ESAs in non-dialysis chronic kidney disease (CKD) is poorly investigated
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Breast cancer trial with erythropoietin terminated unexpectedly
Many clinical studies have shown an association between tumour oxygenation, higher haemoglobin concentrations, and improved survival in patients with cancer.1–6 And, in a recent prospective, randomised study, a subpopulation of anaemic patients with metastatic breast cancer were shown to survive longer if given erythropoietin to correct their haemoglobin concentration during chemotherapy than…
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Darbepoetin alpha in lower-than-equimolar doses maintains haemoglobin levels …
The conversion of patients on stable epoetin therapy to darbepoetin alpha is usually carried out according to the ‘1 mg darbepoetin¼200U epoetin’ rule, which is based on the protein content of the two compounds. Since several observations have suggested that this conversion factor leads to an overestimate of the required darbepoetin dose, the present multicentre study was designed to ass…
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Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease
Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency. Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined.
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Darbepoetin Alfa Effectively Maintains Hemoglobin Concentrations at Extended …
Darbepoetin alfa (KRN321) is a novel molecule that stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Due to its three-fold longer half-life and greater biological activity than recombinant human erythropoietin (rHuEPO), KRN321 maintains an effective hemoglobin (Hb) level at extended dose intervals compared with rHuEPO. In this multicenter, open-label study, 513 dial…
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Comparison of recombinant human erythropoietin and darbepoetin alpha in children
The aim was to compare the clinical efficacy of recombinant human erythropoietin (rHuEPO) and darbepoetin alpha (DA) in the treatment of anemia in children with chronic kidney disease (CKD).
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