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Natural Antibodies Bridge Innate and Adaptive Immunity
Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen elimination, B cell survival and homeostasis, inflammatory diseases, and autoimmunity, there is a lack of clarity about the physiological role of natural IgG and natural IgA because they appear incapable of recognizing Ag…
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Oral proliferative verrucous leukoplakia (PVL); open trial of surgery compare…
Proliferative verrucous leukoplakia (PVL) is a unique oral white lesion in which human papillomavirus (HPV) may play a role. PVL behaves far more aggressively than other forms of leukoplakia with a high rate of recurrence after surgical excision, and relentless progression to verrucous hyperplasia and to verrucous or squamous cell carcinomas. The treatment of PVL is usually by surgery, but ther…
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Effect of inosiplex (Isoprinosine®) on induced human influenza A infection
A double blind prospective controlled study to evaluate the effect of inosiplex in induced human influenza A infection was carried out. Inosiplex was administered in therapeutic (starting 48 h following challenge) or prophylactic-therapeutic (starting 48 h prior to challenge) manner in a dose of 4 g per day. Although the number of volunteers with clinical illness in the two treatment groups wa…
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Inosine pranobex is safe and effective for the treatment of subjects with con…
Inosine pranobex (Isoprinosine®) is an immunomodulatory drug approved in several countries for the treatment of viral infections. This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. Subgroup analyses evaluated the efficacy o…
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Multicenter randomized study of inosine pranobex versus acyclovir in the trea…
The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was conducted in 144 patients with RHL and 144 RHG.
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THE STUDY ON THERAPEUTIC EFFICACY OF INOSINE PRANOBEX IN CHILDREN
Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The objective of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on the immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. Inosine pranobex (50 mg/kg b.w./day) in divide…
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