In this randomized, double blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1mg, 1.0 mg and 3.0mg) of the 5-HT3 receptor antagonist, granisetron (Kytril) as prophylactic therapy for the prevention of postoperative nausea and vomiting
Nausea and vomiting are typical side effects of cytotoxic therapy and some surgical procedures. These symptoms can represent a major therapeutic challenge and, if inadequately controlled by antiemetic treatment, will result in increased mortality, morbidity, and health care costs.
Postoperative nausea and vomiting (PONV) is a frequent complication of surgery. Guidelines recommend using a 5-HT3 receptor antagonist (eg, ondansetron, dolasetron, granisetron) combined with a second agent (eg, dexamethasone) for patients at moderate to high risk for PONV. Although all 5-HT3 antagonists are effective, ondansetron and granisetron have been found to be effective at substantially…
Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy
Your doctor has determined that you have radiation colitis, an inflammation of the colon that occurs as a side effect of cancer radiation therapy to the abdomen or pelvis. The condition can arise from external radiation treatment delivered by a high energy X-ray machine or internal radiation therapy, which is delivered through small implants placed directly into or near the cancerous tumor