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New Trends in the Development of Oral Antidiabetic Drugs
A large number of oral antidiabetic agents are available today. This article provides a short review of the pharmacology and some clinical aspects of various oral antidiabetic drugs. It focuses mainly on the newest developing drugs (therapy of the near future) and on the most commonly used older groups for the common approach of everyday practice (sulphonyureas)
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2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases de…
Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the…
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Diabetes Mellitus–Related All-Cause and Cardiovascular Mortality in a Natio…
Diabetes mellitus is a risk factor for cardiovascular disease (CVD) and has been associated with 2- to 4-fold higher mortality. Diabetes mellitus–related mortality has not been reassessed in individuals receiving routine care in the United States in the contemporary era of CVD risk reduction
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Antidiabetic effects of fermented soybean products on type 2 diabetes
Historically, the incidence of type 2 diabetes has been lower in Asian populations compared with those in Western countries. One possible reason for the lower incidence among Asians is that they consume fermented soybean products, which are unique to the traditional Asian diet. Some have hypothesized that dietary phytoestrogens and soy peptides in fermented soybean foods consumed in traditi…
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The soy isoflavone genistein reverses oxidative and inflammatory state, neuro…
Treatment of diabetes complications remains a substantial challenge. The aim of this study was to explore the ability of the soy isoflavone genistein in attenuating the signs that follow diabetes onset: nociceptive hypersensitivity, oxidative and inflammatory state,nerve growth factor(NGF)decrease and vascular dysfunctions. Genistein (3 and 6 mg/kg) was administered to C57BL/6J streptozotoci…
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Long-term Effects of Metformin on Diabetes Prevention: Identification of Subg…
We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS).
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Strategies for Diabetes Management: Using Newer Oral Combination Therapies Ea…
The duration of uncontrolled type 2 diabetes mellitus (T2DM) can adversely impact small and large vessels, eventually leading to microvascular and macrovascular complications. Failure of therapeutic lifestyle changes, monotherapy, and clinical inertia contribute to persistent hyperglycemia and disease progression.
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Use of Oral Anti-Diabetic Agents in Pregnancy: A Pragmatic Approach
Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when lifestyle measures do not maintain glycemic control during pregnancy. However, recent studies have suggested that certain oral hypoglycemic agents (metformin and glyburide) may be safe and be acceptable alternatives. There are no serious safety concerns with metformin, despite it crossing the placenta.
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Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practic…
The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults.
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KONSENSUS PENGELOLAAN DAN PENCEGAHAN DIABETES MELITUS TIPE 2 DI INDONESIA : 2015
Hiperglikemia adalah suatu kondisi medik berupa peningkatan kadar glukosa dalam darah melebihi batas normal. Hiperglikemia merupakan salah satu tanda khas penyakit diabetes mellitus (DM), meskipun juga mungkin didapatkan pada beberapa keadaan yang lain. Saat ini penelitian epidemiologi menunjukkan adanya kecenderungan peningkatan angka insidensi dan prevalensi DM tipe-2 di berbagai penjuru du…
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