2014 NSTE ACS Guidelines Overview

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Extended dual antiplatelet therapy for Asian patients with acute coronary syn…

Recommendations were produced for the following nine risk factors: old age (>65), chronic kidney disease (CKD), diabetes mellitus (DM), recurrent myocardial infarction (MI), multi-vessel disease (MVD), multiple stents, bioresorbable vascular scaffold (BVS) stent, left main stenting and peripheral artery disease (PAD). Strong ischaemic risk factors include DM, recurrent MI, MVD and/or >3 stents;…

Treatment of right heart failure: is there a solution to the problem?

Right heart function is a significant determinant of outcomes across a variety of aetiologies of rightrnventricular (RV) dysfunction. Right heart failure syndrome is characterised by the inability of the rightrnventricle to generate sufficient stroke volume. Management often requires simultaneous execution ofrnmultiple strategies to optimise RV preload, contractility and afterload, while mainta…

Efficacy and safety of ticagrelor versus clopidogrel in acute coronary syndro…

Ticagrelor treatment could provide a marginally favorable effect at the expense of an increased risk of dyspnea n real-life situations. This pilot study provides a scientific basis to call for a larger, suitably powered Phase 4 prospective or observational study in this ethnic population.

Systematic review: portal vein thrombosis in cirrhosis

Portal vein thrombosis is encountered in 10–25% of cirrhotics. In terms of pathophysiology, cirrhosis is no longer considered a hypocoagulable state; rather than a bleeding risk in cirrhosis, various clinical studies support a thrombotic potential. Clinical findings of portal vein thrombosis in cirrhosis vary from asymptomatic disease to a life-threatening condition at first presentation

Heart Failure in the diabetic patient – epidemiology, etiology, prognosis, …

In the type 2 diabetic patient the frequency of heart failure (HF) is increased and the mortality from HF is higher than with non-diabetic HF. The increased frequency of HF is due to the cardiotoxic tetrad of ischemic heart disease, left ventricular hypertrophy, diabetic cardiomyopathy and an extracellular volume expansion resistant to atrial natriuretic peptides

Pharmacokinetics and Side-Effects of Clonidine

single oral dose of clonidine 309 ~tg was administered to 8 healthy, normotensive subjects and the time course of its plasma concentrations was followed for 24 h.

Cardiovascular Management in Pregnancy: Congenital Heart Disease

Marked advances in the treatment of congenital heart disease (CHD) have resulted in a growing population of adults with CHD, currently estimated at >1 million adults (at least equal to the pediatric population).1 Many of these are young women, facing decisions about childbearing, and will require expert care. A recent analysis of a large nationally representative hospital discharge database in…

Acquired Hemophilia: A Report of 4 Cases

Acquired hemophilia A is very rare and often causes life-threatening hemorrhage. We report 4 cases of this disorder in different settings. Case1 received activated protrombin concentrate complex (aPCC) and the result was excellent

Management of bleeding in acquired haemophilia A with recombinant activated f…

Acquired haemophilia A (AHA) is a rare but clinically relevant bleeding disorder due to autoantibodies (inhibitors) against coagulation factor VIII (FVIII