S-index and APRI Score to Predict Liver Fibrosis Chronic in Hepatitis B and C…

A great interest has been dedicated to the development of non invasive predictive models in recent years to substitute liver biopsy for fibrosis assessment and follow-up. The aim of this study was to compare the accuracy between S-index and aspartate aminotransferase to platelet ratio index (APRI) to FibroScan for predicting liver fibrosis in chronic hepatitis B and C patients

The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde

Chronic hepatitis B (CHB) is a major health problem worldwide and is associated with significant long-term morbidity and mortality. The hepatitis B virus (HBV) is a hepatotropic virus that is capable of integrating in the host nucleus permanently resulting in lifelong infection. To date, there is no definitive cure for HBV, as our current treatments cannot eradicate the viral reservoir that ha…

Impact of age on the diagnostic performances and cut-offs of APRI and FIB-4 f…

The APRI AUROC in patients aged

AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fi…

Liver biopsy is the recognized gold standard for liver fibrosis staging. The aspartate minotransferase to platelet ratio index (APRI) has been proposed as a noninvasive and readily available tool for the assessment of liver fibrosis in chronic hepatitis C (CHC). This study aimed to validate, in a Mexican tertiary health care setting, the diagnostic usefulness of APRI in CHC, nonalcoholic fatty…

The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill

The administration of intravenous fluids to maintain or increase intravascular volume is a common intervention in the intensive care unit (ICU). There has been an enduring controversy as to the impact of the choice of resuscitation fluid on patients’ outcomes [1–7]. In particular, there are no adequately powered randomized controlled trials examining the impact of resuscitation fluid cho…

Randomised trials of human albumin for adults with sepsis: systematic review …

In this analysis, human albumin solutions as part of fluid volume expansion and resuscitation for critically unwell adults with sepsis of any severity (with or without baseline hypoalbuminaemia) were not robustly effective at reducing all-cause mortality. Albumin seems to be safe in this setting, as a signal towards harm was not detected, but this analysis does not support a recommendation for use

Albumin administration improves organ function in critically ill hypoalbumine…

Albumin administration may improve organ function in hypoalbuminemic critically ill patients. It results in a less positive fluid balance and a better tolerance to enteral feeding

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A paradigm for consensus. The University Hospital Consortium guidelines for t…

The Delphi method, a systematic, literature-based consensus process, was shown to be useful in the development of complex clinical practice guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions. It is anticipated that the guidelines will assist health care providers to develop local institutional policies and procedures for the appropriate and efficient use of albumin…