Peripheral Arterial Disease

Peripheral arterial disease (PAD) is a chronic atherosclerotic process that causes narrowing of the peripheral arterial vasculature, predominantly of the lower limbs. It has an estimated worldwide prevalence of up to 10%, increasing to nearly 30% in patients more than 50 years of age.1 Critical limb ischemia (CLI), the most severe manifestation of the disease, can result in limb loss, or even …

Classical Renin-Angiotensin System in Kidney Physiology

The renin-angiotensin system has powerful effects in control of the blood pressure and sodium homeostasis. These actions are coordinated through integrated actions in the kidney, cardiovascular system and the central nervous system. Along with its impact on blood pressure, the renin-angiotensin system also influences a range of processes from inflammation and immune responses to longevity. Her…

Treatment of Severe Diphtheritic Myocarditis by Temporary Insertion of a Card…

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The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy

Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection. Recent experimental studies revealed complex regulatory roles for several microribonucleic acids and T-cell and macrophage subtypes.

Clinical Features and Predictors of Diphtheritic Cardiomyopathy in Vietnamese…

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Migraine and risk of cardiovascular diseases: Danish population based matched…

To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort.

Cardiovascular outcomes associated with canagliflozin versus other non-gliflo…

To evaluate the cardiovascular safety of canagliflozin, a sodium-glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus, in direct comparisons with DPP-4 inhibitors (DPP-4i), GLP-1 receptor agonists (GLP-1RA), or sulfonylureas, as used in routine practice.

Cancer risk associated with chronic diseases and disease markers: prospective…

To assess the independent and joint associations of major chronic diseases and disease markers with cancer risk and to explore the benefit of physical activity in reducing the cancer risk associated with chronic diseases and disease markers

Achieving a Maximally Tolerated b-Blocker Dose in Heart Failure Patients Is T…

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Pediatric Cardiology Centers: Cooperation Versus Competition

After completing my fellowship training in the early 1990s, I joined a tertiary care center in Chicago. I was surprised to see a plethora of pediatric cardiology programs, all in one city. The pediatric cardiology center where I trained was in a small town in the southeastern region of the USA