Primary percutaneous coronary intervention is the gold-standard treatment for acute coronary artery occlusion. This is primarily diagnosed by ST segment elevation on an ECG accompanying ischaemic-sounding chest pain.
In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKDrnpatients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversialrndue to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for thosernwith CKD. Until studi…
Renin substrate, biological renin activity, and/or renin-secreting cells in kidneys evolved at an early stage of vertebrate phylogeny. Angiotensin (Ang) I and II molecules have been identified biochemically in representative species of all vertebrate classes, although variation occurs in amino acids at positions 1, 5, and 9 of Ang I. Variations have also evolved in amino acid positions 3 and 4 …
The effects of renin–angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) on cancer remain inconsistent
Ever since the publication of the SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) in 2006, neurologists became aware of the fact that statins may increase the risk for future intracerebral hemorrhage (ICH) in patients with previous ischemic stroke or ICH.1,2 At the same time, observational studies reported an increased risk for hemorrhagic transformation or even…
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDLcholesterol. Statins may exert cardiovascular protective effects that are in…
The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally indu…
Sepsis is a clinical syndrome that requires prompt recognition andrncontrol in order to optimize clinical outcomes in patients. It is very relevantrnto surgical practice, as it can affect perioperative patients andrnthose recovering on surgical wards. A working knowledge of sepsisrnis essential to any medical or surgical practitioner, and here werncover the topic with relevance to surgery and t…
Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitiv…
The groups were statistically similar with regards to baseline clinical and demographic features. The values of C-reactive protein, white blood cell and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in study group versus control group, but none of them were considered as an independent predictor of peripheral arterial disease according to multivar…