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Relationships between serum uric acid and blood pressure, metabolic variables…
These data provide evidence that similarly to what described in western Europe, in central and eastern European countries SUA values are closely related to metabolic alterations, including diabetes mellitus, to renal insuffi ciency and CV risk profi le. At variance from other studies, however, no relationship was found with BP control.
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Novel therapies for diabetic kidney disease
Over the past 30 years there have been many complementary therapies developed to achieve glycemic control and have an impact on cardiovascular outcomes, as well as reduce the risk of microvascular disease. The 2 most notable new entries have been the sodium–glucose cotransporter 2 (SGLT2) inhibitors and the glucagon-like peptide-1 (GLP-1) agonists. Both these classes of agents have demonstra…
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Mineralocorticoid Antagonism and Diabetic Kidney Disease
Type 2 diabetes (T2D) is associated with an increased risk of diabetic kidney disease (DKD), cardiovascular disease, and heart failure, in part through activation of the renin-angiotensin-aldosterone system (RAAS). Although recent cardiovascular outcome trials have identified newer therapeutic agents such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1)-…
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Cardiovascular outcomes in diabetic kidney disease: insights from recent clin…
The prevalence of type 2 diabetes is catalyzing a pandemic in kidney disease, with ensuing cardiovascular complications. The effort to identify antidiabetic agents capable of promoting benefits that go beyond the bounds of glucose control has produced remarkable outcomes in recent cardiovascular outcomes trials in patients with type 2 diabetes mellitus, many of whom have diabetic kidney disease.
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Cervical Root Syndrome
The clinical manifestations of the cervical root syndrome may mimic the symptoms of coronary artery disease so closely that errors in diagnosis are common. Complaint of pain in the left side of the chest and arm is insufficient grounds for making a diagnosis of coronary artery disease.
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Strategies to increase nitric oxide signalling in cardiovascular disease
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central nervous systems, and crucial steps in the regulation of NO bioavailability in health and disease are well characterized. Although early approaches to therapeutically modulate NO bioavailability failed in clinical trials, an enhanced understanding of fundamental subcellular signalling has enabled a range of …
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The Prognostic Significance of Carotid Intima-Media Thickness in Patients Who…
Objectives：Increased carotid intima-media thickness (IMT) is known to be associated with adverse cardiovascular events in the patients with risk factors or established atherosclerosis. However, the prognostic importance of carotid IMT is uncertain in the patients who underwent percutaneous coronary intervention (PCI). We sought to evaluate the association of carotid IMT with major adverse …
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Association of increased carotid intima-media thickness with the extent of co…
To investigate (a) the relation between intima-media thickness (IMT) in carotid arteries and the extent of coronary artery disease (CAD); and (b) whether IMT is predictive of coronary atherosclerosis. The coexistence of severe extracranial atherosclerosis in patients with CAD was also analysed
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Safety of New Oral Anticoagulants for Patients with Chronic Kidney Disease
In daily practice, chemical substances called “direct oral anticoagulants” or DOACs are more convenient to administer when set beside vitamin K antagonists (VKA) due to improved pharmacologic properties, fewer drug interactions and rapid onset of action. The objective of this review was to assess whether DOACs are the alternative for VKA in subjects with mild-to-moderate chronic kidney d…
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Efficacy and safety of statin therapy in older people: a meta-analysis of ind…
Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range ofrnindividuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysisrnof data from all large statin trials to compare the effects of statin therapy at different ages.
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