Assessing the severity of acute pulmonary embolism-manuscript-2019

Acute pulmonary embolism (PE) is potentially fatal due either to a first massive episode or early recurrence; however, if diagnosed early, it can be effectively treated and in most cases cured. PE episodes have a wide spectrum of severity: from asymptomatic, detected incidentally to life-threatening with haemodynamic collapse. Consequently, optimal treatment may range from anticoagulant pills t…

Bioequivalence study of two clopidogrel film-coated tablet formulations in he…

The present study was performed to compare the bioavailability of two clopidogrel 75 mg film-coated tablet formulations (test formulation and reference formulation). This study was a randomized, single-blind, two-period, two-sequence cross-over study which included 24 healthy adult male and female subjects under fasting condition. The pharmacokinetic parameters were assessed based on the concen…

The importance of bioequivalence study: focus on clopidogrel

Bioequivalence (BE) study is required to show whether a generic copy product can be interchangeable with the brand innovator product. The aim of this article is to provide the rationale for conducting BE studies, the main products requiring BE studies, the design and conduct of BE studies in general, with focus on clopidogrel. All of the clopidogrel generic products in Indonesia have been shown…

The Role of Clopidogrel in 2020: A Reappraisal

Antiplatelet therapy is the mainstay of treatment and secondary prevention of cardiovascular disease (CVD), including acute coronary syndrome (ACS), transient ischemic attack (TIA) or minor stroke, and peripheral artery disease (PAD). *e P2Y12 inhibitors, of which clopidogrel was the first, play an integral role in antiplatelet therapy and therefore in the treatment and secondary prevention of …

Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo …

Vestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether these effects persist after treatment cessation

Risk Factors for Stroke in the Chinese Population

Stroke is the leading cause of death in China. According to the Chinese Stroke Screening and Prevention Project, 8 main risk factors were assessed and individuals with 3 or more risk factors were identified as high-risk population of stroke. To explore the potential impropriety of counting the risk factors but ignoring the different strength of association of each risk factor, we performed thi…

Wound Healing and Skin Regeneration

The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used i…

Vitamins in early pregnancy

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Evaluation of vehicle substances on vitamin D bioavailability: A systematic r…

Vitamin D insufficiency is a common medical condition. Vitamin supplements can be ingested to improve vitamin D status. It is not known if the vehicle substance that is combined with the vitamin D tablet influences the bioavailability of vitamin D. The purpose of this review is to examine the impact of different vehicles on vitamin D bioavailability. A comprehensive literature search identified…

Assessing the severity of acute pulmonaryrnembolism: back to the future?

This editorial refers to ?Prognostic value of right ventricularrndysfunction or elevated cardiac biomarkers in patients withrnlow-risk pulmonary embolism: a systematic review andrnmeta-analysis?? by S. Barco et al.,