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MicroRNAs in Acute Myocardial infarction: Evident Value as Novel Biomarkers?
Traditional circulating biomarkers play a fundamental role in the diagnosis and prognosis of acute myocardial infarction (AMI). However, they have several limitations. microRNAs (miRs), a class of RNA molecules that do not encode proteins, function directly at the RNA level by inhibiting the translation of messenger RNAs. Due to their significant roles in disease development, they can be used a…
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Identification of microRNAs as Diagnostic Biomarkers for Acute Myocardial Inf…
Acute myocardial infarction (AMI) is one of the leading causes of mortality and morbidity worldwide. Recently, several studies have revealed the diagnostic value of circulating microRNAs (miRNAs) for AMI detection. However, the diagnostic capacity of miRNAs for AMI is still controversial due to the inconsistent results among studies
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Effect Initial Heart rate Cardiac Troponin & Ejection Fraction on patients wi…
Increased heart rate has shown to be associated with adverse cardiovascular outcomes. This aim of this study was to find the association of troponin level and ejection fraction (EF) with triage heart rate in patients with non-ST elevation myocardial infarction (NSTEMI). It was hypothesized that heart rate at triage will be independently associated with higher troponin level and lower EF after N…
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Spironolactone vs placebo, Bisoprolol, and Doxazin to Determine the Optimal T…
Optimal drug treatment for patients with resistant hypertension is undefi ned. We aimed to test the hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone would therefore be superior to non-diuretic add-on drugs at lowering blood pressure.
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Premature Ventricular Contraction Coupling Interval Variability Destabilizes …
Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system (ICNS), a neural network on the heart, remai…
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Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model
Thirty-three million people have atrial fibrillation (AF), a disorder of heart rhythm.1 Over the past several decades, we have learned that this dysrhythmia originates in the interplay between genetic predisposition, ectopic electrical activity, and abnormal atrial tissue substrate and then feeds back to remodel and worsen tissue substrate and, thereby, propagates itself.
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Silent Cerebral Embolism during Atrial Fibrillation Ablation: Pathophysiology…
Although many efforts have been directed to improve atrial fibrillation transcatheter ablation safety, thromboembolism to the brain remains one of the major complications. In fact several studies have confirmed occurrence of silent cerebral embolic lesions by post-procedure magnetic resonance imaging, the present review will focus on the possible mechanisms leading to silent cerebral embolism i…
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Anticoagulant treatment in COVID‑19: a narrative review
The actual Coronavirus Disease (COVID 19) pandemic is due to Severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2), a member of the coronavirus family. Besides the respiratory involvement, COVID 19 patients frequently develop a pro-coagulative state caused by virus-induced endothelial dysfunction, cytokine storm and complement cascade hyperactivation. It is common to observe diffuse m…
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Anticoagulation in COVID – 19: An Update
The novel coronavirus disease, 2019 (COVID – 19) evolved as an unprecedented pandemic. The severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) infection has been associated with significantly deranged coagulation parameters and increased incidence of thrombotic events. Deranged coagulation parameters, such as D-dimers and fibrin degradation products, can indicate a poor prognosis…
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Coagulation and anticoagulation in COVID-19
COVID-19 has become a pandemic in the United States and worldwide. COVID-19-induced coagulopathy (CIC) is commonly encountered at presentation manifested by considerable elevation of D-dimer and fibrin split products but with modest or no change in activated partial thromboplastin time and prothrombin time. CIC is a complex process that is distinctly different from conventional sepsis-induced c…
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