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Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An…
The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms. Apart from the well known systemic RAS, occurrence of a local RAS has been documented in multiple tissues, including the kidney. A large body of recent evidence frompharmacologic and genetic studies, particularly those using various transgen…
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Impact of Baseline Bleeding Risk on Efficacy and Safety of Ticagrelor versus …
Among the 20,816 eligible PCI patients who were included in this study, there were 1578 and 779 patients in the clopidogrel and ticagrelor groups, respectively, after PSM, their clinical parameters were well matched. Patients receiving ticagrelor showed comparable NACE risk compared with those treated by clopidogrel (5.3% vs. 5.1%, P = 0.842). Furthermore, ticagrelor might reduce the MACCE ris…
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Anaemia in kidney disease: harnessing hypoxia responses for therapy
Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the p…
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Pathophysiology of renal anaemia
Anaemia remains a prominent feature of chronic kidney disease (CKD). The prevalence is inversely correlated with kidney function, and the vast majority of patients with CKD Stage 5 develop anaemia [
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Uji Klinik Buta Ganda Perbedaan Profil Perdarahan Dan Outcome Klinis Pasien S…
DLBS1033 adalah enzim protease fibrinolitik yang bekerja menghidrolisis fibrin atau fibrinogen dan menstimulasi plasminogen menjadi plasmin. Plasminogen activator (e-PA) pada DLBS1033 mirip dengan tissue plasminogen activator (t-PA), sehingga memungkinkan adanya aktivitas trombolitik terhadap fibrin.
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DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic…
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. F…
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Guidelines on the diagnosis and management of acute pulmonary embolism
Guidelines and Expert Consensus Documents summarize and evaluate all currently available evidence on a particular issue with the aim of assisting physicians in selecting the best management strategies for a typical patient, suffering from a given condition, taking into account the impact on outcome, as well as the risk/benefit ratio of particular diagnostic or therapeutic means. Guidelines ar…
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Prediction of postpartum hemorrhage in women with gestational hypertension or…
To assess whether postpartum hemorrhage can be predicted in women with gestational hypertension or mild preeclampsia at term. Design. A cohort study in which we used data from our multicentre randomized controlled trial (HYPITAT trial). Setting. The study was conducted in 38 hospitals in the Netherlands between 2005 and 2008.
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Heart failure drug treatment
Heart failure is the most common cardiovascular reason for hospital admission for people older than 60 years of age. Few areas in medicine have progressed as remarkably as heart failure treatment over the past three decades. However, progress has been consistent only for chronic heart failure with reduced ejection fraction. In acutely decompensated heart failure and heart failure with preser…
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Atrial fibrillation and stroke: a practical guide
Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly in…
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