Phase III randomized clinical trial of efficacy and safety of amlodipine and …

Effective antihypertensive therapy is essential for achieving optimal blood pressure (BP) control and reducing cardiovascular events. This double-blind, multicenter, randomized trial aimed to compare the antihypertensive efficacy and safety of a combination of amlodipine (AML) and candesartan cilexetil (CC) versus AML monotherapy in patients with essential hypertension (HTN). After a 4-week run…

Pengaruh pemberian ekstrak Psidium guajava terhadap jumlah trombosit pada pen…

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Dengue in Travelers

Dengue virus infection is increasingly recognized as one of the world’s major emerging infectious diseases. Dengue is endemic in most tropical and subtropical countries, many of which are popular tourist destinations. International travelers may both acquire and spread dengue virus infection. Health care providers need to understand the epidemiology, risk factors, clinical spectrum, diagnosi…

Micronutrients in health and disease

Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical deficiency, often of multiple micronutrients, is more difficult to recognise, a…

Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus…

Micronutrients, an umbrella term used to collectively describe vitamins and trace elements, are essential components of nutrition. Those requiring alternative forms of nutrition support are dependent on the prescribed nutrition regimen for their micronutrient provision. The purpose of this paper is to assist clinicians to bridge the gap between the available guidelines’ recommendations and th…

The Influence of Molecular Size on Drug Absorption: A Comprehensive Overview

The process of drug absorption is a critical determinant in the pharmacokinetics of therapeutic agents. Among the various factors influencing drug absorption, the molecular size stands out as a key parameter. This article delves into how molecular size affects drug absorption, exploring the mechanisms involved, the challenges presented, and the strategies employed to optimize drug delivery for …

Hydration-Induced Structural Changes in the Solid State of Protein:A SAXS/WAX…

The stability of biologically produced pharmaceuticals is thelimiting factor to various applications, which can be improved by formulationin solid-state forms, mostly via lyophilization. Knowledge about the proteinstructure at the molecular level in the solid state and its transition uponrehydration is however scarce, and yet it most likely affects the physical andchemical stability of the biol…

Pharmaceutical Coating and Its Different Approaches, a Review

Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating …

Potential effect of striatin (DLBS0333), a bioactive protein fraction isolate…

To characterize proteins and other nutrients in striatin (DLBS0333), a bioactive protein fraction isolated from snakehead fish (Channa striata) and to investigate its wound healing activity

Randomized Controlled Trial on the Effect of Channa striatus Extract on Measu…

To compare the mean of anteroposterior (AP) measurements of the uterus in longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine artery and superficial skin wound artery between patients taking Channa striatus and placebo.