A cute kidney injury (AKI) is a very common problem in critically ill patients. With the integration of consensus AKI definition criteria from Risk, Injury, Failure, Loss, End-Stage Kidney Disease (RIFLE), Acute Kidney Injury Network (AKIN), and, most recently Kidney Disease Improving Global Outcomes (KDIGO), AKI incidence in adult intensive care unit (ICU) settings has been reported to range b…
Dari 411 pasien yang dirawat di Unit Perawatan Intensif Anak, 149 (36,25%) dilakukan pemeriksaan blood urea nitrogen (BUN) dan serum kreatinin (SC). Terdapat 25 kasus (6,1%) merupakan kasus AKI. Sebagian besar subyek berusia di bawah 1 tahun (10/25) dan berjenis kelamin laki-laki 15/25. Berdasarkan kriteria pRIFLE, 3 termasuk dalam kriteria risk (R), 12 injury (I), dan 10 dimasukkan failure (F)…
The prevalence of septic acute kidney injury (AKI) and impact on functional status of pediatric intensive care unit (PICU) survivors are unknown. We utilized data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic AKI.
Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the…
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive,rnlong-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arisingrnfrom research in the past 10 years have increased understanding of this problem among clinicians and lay people, andrnhave led to improved outcomes. The World Hea…
Hypertension (HTN) is among the most common, noncommunicable disease in the world. Approximately 80 million people (32.6%) in the United States [1] and one billion worldwide suffer from HTN [2], and the prevalence may be even higher as the diagnosis is based on an objective test (i.e., blood pressure measurement). Longterm HTN leads to hypertensive heart disease, and is the result of anatomical…
Pressure loss vs. flow curves offer a fundamental fluid dynamic synthesis for describing aortic valve pathophysiology. Severe AS does not consistently behave like an orifice (as suggested by Gorlin) or a resistor, whereas TAVI devices behave like a pure resistor. During peak dobutamine, the ratio of aortic to left ventricular pressures during systolic ejection provides a ‘fractional flow r…
Eight studies involving 105,861 participants were eligible. New LBBB was associated with higher mortality at 30 days (OR: 2.10, 95% CI 1.27 to 3.48) and 1-year follow up (OR: 2.81, 95% CI 1.64 to 4.80), and increased heart failure risk (OR: 2.64, 95% CI 1.84 to 3.77).
Six children with primary Raynaud's disease have been studied with plethysmography and multiple-site skin-temperature readings. All six were free of systemic disease. Each demonstrated the characteristic sequence of pallor, cyanosis, and rubor when subjected to generalized cold, but application of local cold produced only modest reduction in skin temperature and digital pulse. Only one child ha…
We report five children who presented with Raynaud's disease in whom we could find no clinical, haematological, or immunological evidence of a collagen disorder. Oral phenoxybenzamine proved useful for maintenance treatment in most, with infusions of prostacyclin, nitroprusside, and ketanserin during acute attacks