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Domperidone a review of its pharmacodynamic activity, pharmacokinetics therap…
Domperidone is a dopamine antagonist that does not readily enter the central nervous system. Given parenterally or orally it increases gastric emptying of liquids and increases lower oesophageal sphincter pressure in healthy subjects. The antiemetic and pharmacodynamic profile of domperidone is similar to that of metoclopramide, although domperidone has a lower propensity to cause extrapyramida…
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P-Glycoprotein in the Blood-Brain Barrier of Mice Influences the Brain Penetr…
The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine, digoxin, and cyclosporin A in the brain. We show here that the drugs loperamide, domperidone, and ondansetron are transported substrates for the mouse mdr1a P-GP and its human homologue MDR1. Phenytoin is a rel…
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A New Method of Characterizing the Buccal Dissolution of Drugs
Over the last several years there has been a great increase in interest for liquid and dissolve-in-the-mouth dosage forms. This interest is spurred by the promise of improved patient compliance compared to tables and capsules, that have to be swallowed whole
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Dissolution Testing of Orally Disintegrating Tablets
Orally disintegrating tablets (ODT) are solid dosage forms that disintegrate in the oral cavity leaving an easy-to-swallow residue.The disintegration times are generally less than one minute.For orally disintegrating tablets,taste-masking of bitter or objectional-tasting drug substances is critical.The taste-masking aspect plays a significant role in dissolution method development,specification…
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Fast-Melting Tablets: Developments and Technologies
The demand for fast-melting tablets (FMTs) has been growing during the last decade, particularly for children and the elderly who have difficulty swallowing tablets and capsules.
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New Formulation of Fast-Melting Tablets: Vometa FT as a Case Study
The demand of fast-melting tablets has been growing during the last decade. This dosage form is placed in the mouth, allowed to disperse or dissolve in the saliva, and then swallowed. In addition, it can be administered anywhere, without the need for water or chewing. Due its features, the fast-melting tablets will increase patient compliance, especially those who need rapid relief, such as vom…
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Cardiac Safety and Clinical Efficacy of High Dose Domperidone for Long-Term T…
Domperidone (D), a dopamine 2 receptor antagonist, is an effective anti-emetic that acts at the chemoreceptor trigger zone and only minimally crosses the blood brain barrier while also exerting prokinetic effects on the stomach and proximal small bowel. D is not approved in the USA. Recommended dosing worldwide is 30 mg/day and due to scattered reports of cardio toxicity ECG monitoring is reco…
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Effect of Domperidone on the Health-Related Quality of Life of Patients With …
To describe the health-related quality of life (HRQOL) of patients with insulin - t reated diabetes and symptoms of diabetic gastro p a resis and to assess the impact of domperidone on HRQOL in these patients
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Evaluation and management of variceal bleeding
Acute variceal bleeding is one of the most fatal complications of cirrhosis and is responsible for about one-third of cirrhosis-related deaths.Therefore,every effort should be made to emergently resuscitate the patients,start pharma-cotherapy as soon as possible and do endoscopic therapy in a timely manner. Despite there cent advances in treatment, mortality rate is still high.We provide a comp…
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Radiation Colitis and Proctitis
Radiation therapy is commonly utilized as a major component in the treatment of pelvic malignancy. Unfortunately, secondary toxicity to the lower gastrointestinal tract can occur. This most commonly affects the rectum, although injuries to the colon and small intestine are not uncommon. The presentation can be acute or chronic, and different mechanisms are responsible for each. Symptomatology i…
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