This study aimed to investigate the safety and efficacy of ambroxol hydrochloride in combination with procaterol hydrochloride in treating pediatric pneumonia and their effects on plasma tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-18. Methods: A total of 86 children with pneumonia were selected and divided into group A (n=43) (received routine pneumonia treatment) and group B …
Clinical practice guidelines (CPGs) recommending palonosetron for the prevention and management of chemotherapy-induced nausea and vomiting (CINV) were adapted for use at our institution. Palonosetron was restricted for use in patients experiencing breakthrough CINV and receiving highly emetogenic chemotherapy (HEC) or undergoing stem cell transplant conditioning and in patients with refract…
Cough in children is among the most common symptoms and may have a deep impact on children’s and parents’ sleep and quality of life, thus often requiring an empiric treatment with antitussive agents. Levodropropizine is a very well tolerated peripheral drug, while central cough suppressants (opioids and non opioids) may be associated with side effects that limit their use especially in chil…
We included 133 studies with 4243 ADRs reported in 197,675 neonates, infants, and children who received azithromycin. The safety of azithromycin as MDA in pediatrics was poorly monitored. The main ADRs were diarrhea and vomiting. In prospective non-MDA studies, the most common toxicity was gastrointestinal ADRs (938/1967; 47.7%). The most serious toxicities were cardiac (prolonged QT or irregul…