PRODUCT LITERATURE

Differential effects of the charge variants of human follicle-stimulating hormone

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FSH is synthesized and secreted by the anterior pituitary gland in multiple molecular forms; the release of these isoforms depends on the endocrine status of the donor at the time of sample collection. In the present study, we analysed the possibility that the FSH charge isoforms may exert differential effects at the target cell. Seven FSH isoform mixes were isolated from pooled anterior pituitary glycoprotein extracts by high resolution chromatofocusing,
followed by affinity chromatography, which removed nearly 90% of the LH that co-eluted with the FSH isoforms during chromatofocusing. The isoforms (isoform I, pH >7·10; II, pH range 6·60–6·20; III, pH 5·47–5·10; IV, pH 5·03–4·60; V, pH 4·76–4·12; VI, pH 4·05–3·82 and VII, pH

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Publisher

: .,

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Language

English

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Classification

NONE

Content Type

LITERATURE

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Edition

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Subject(s)

Fostimon

Specific Detail Info

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Statement of Responsibility

Journal of Endocrinology (2000) 165, 193–205

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