Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial

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Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial

Ji, SH - Personal Name;

Anesthetic exposure in young children raises concerns about neurodevelopmental safety, with preclinical evidence suggesting potential neurotoxicity of volatile anesthetics. This study aimed to assess whether the combination of dexmedetomidine and remifentanil, by reducing sevoflurane exposure, has any differential effect on neurodevelopmental outcomes in young children compared with sevoflurane alone.

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Sevodex-009

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Language: English
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Content Type: LITERATURE
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Subject(s): Sevodex
Dexmedetomidine
Inhalation Anesthesia
Specific Detail Info: Anesthesiology 2025; 143:827–34
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