PRODUCT LITERATURE

Aldosterone’s Rapid, Nongenomic Effects Are Mediated by Striatin: A Modulator of Aldosterone’s Effect on Estrogen Action

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The cellular responses to steroids are mediated by 2 general mechanisms: genomic and rapid/ nongenomic effects. Identification of the mechanisms underlying aldosterone (ALDO)’s rapid vs their genomic actions is difficult to study, and these mechanisms are not clearly understood. Recent data suggest that striatin is a mediator of nongenomic effects of estrogen. We explored the hypothesis that striatin is an intermediary of the rapid/nongenomic effects of ALDO and that
striatin serves as a novel link between the actions of the mineralocorticoid and estrogen receptors. Inhumanandmouseendothelial cells,ALDOpromoted an increase in phosphorylated extracellular signal-regulated protein kinases 1/2 (pERK) that peaked at 15 minutes

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: .,

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Language

English

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NONE

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LITERATURE

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Subject(s)

Posafit
Aldosterone

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Statement of Responsibility

Endocrinology 155: 2233–2243, 2014

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