Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-kB-TNFa-caspase-8 pathway

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Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-kB-TNFa-caspase-8 pathway

Berlian, G - Personal Name;

The data support our hypothesis that Proliverenol has a potential ability in protecting cells from ethanol-induced hepatotoxicity. We propose that Proliverenol provides hepatoprotective activity through up-regulating expression of APEX1 that repress DNA fragmentation, and down-regulating expression of nuclear factor-kB, tumor necrosis factora and caspase-8, which therefore repress ALT leakage and its expression

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Veprolin-003

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Language: English
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Classification: NONE
Content Type: LITERATURE
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Subject(s): Phaleria macrocarpa
Proliverenol
Veprolin
Specific Detail Info: Asian Pac J Trop Biomed 2016; 6(8): 686–691
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